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SMARCA4 and HIST2H3C
Number of citations of the paper that reports this interaction (PMID
17274598
)
34
Data Source:
BioGRID
(unspecified method)
SMARCA4
HIST2H3C
Gene Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
histone cluster 2, H3c
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromatin
Heterochromatin
Extracellular Space
Nucleus
Nucleoplasm
Nuclear Euchromatin
Perichromatin Fibrils
Nucleolus
Membrane
SWI/SNF Complex
Protein Complex
NpBAF Complex
NBAF Complex
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
RNA Polymerase II Transcription Coactivator Activity
P53 Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Helicase Activity
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Tat Protein Binding
Nucleosomal DNA Binding
Protein N-terminus Binding
Androgen Receptor Binding
DNA Polymerase Binding
Lysine-acetylated Histone Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Morphogenesis
Vasculogenesis
Blastocyst Growth
Blastocyst Hatching
Liver Development
Neural Retina Development
Chromatin Organization
Nucleosome Disassembly
Chromatin Remodeling
Methylation-dependent Chromatin Silencing
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Glial Cell Fate Determination
DNA Methylation On Cytosine Within A CG Sequence
Stem Cell Maintenance
Positive Regulation Of Wnt Signaling Pathway
Extracellular Matrix Organization
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
Forebrain Development
Hindbrain Development
Embryonic Hindlimb Morphogenesis
Aortic Smooth Muscle Cell Differentiation
ATP-dependent Chromatin Remodeling
Positive Regulation Of DNA Binding
Positive Regulation By Host Of Viral Transcription
Histone H3 Acetylation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Embryonic Organ Morphogenesis
Epidermis Morphogenesis
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Definitive Erythrocyte Differentiation
Heart Trabecula Formation
Negative Regulation Of Androgen Receptor Signaling Pathway
Lens Fiber Cell Development
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Chromatin modifying enzymes
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
formation of the beta-catenin:TCF transactivating complex
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by Wnt
Signaling by WNT in cancer
RMTs methylate histone arginines
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Coronary heart disease (
21347282
)
Protein-Protein Interactions
73 interactors:
ACTB
ACTL6A
AHR
AR
ARID1A
ARID1B
ARID2
BRCA1
BRWD1
CARM1
CBX5
CCNE1
CDK19
CDK8
CDKN2A
CDX2
CEBPA
CEBPB
CHD4
CHMP5
CIITA
CREB1
CTNNB1
DPF3
ESR1
ETS2
FANCA
GATA1
GMNN
H2AFX
H3F3A
HIST1H3A
HIST1H4F
HIST2H2BE
HIST2H3C
HSF1
HSF4
IKZF1
KLF1
MBD3
MDM2
MED17
MED6
MKL1
MPHOSPH6
MPP6
MYC
MYOCD
NR3C1
NR4A2
PABPN1
PAX6
PBRM1
PHB
RAP1A
RB1
RBL1
RBL2
RELB
RFXAP
SIN3A
SIN3B
SMARCB1
SMARCC1
SMARCE1
SS18
SS18L1
STAT2
STAT3
STK11
TMF1
TP53
ZMYND11
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
Entrez ID
6597
126961
HPRD ID
04459
11822
Ensembl ID
ENSG00000127616
Uniprot IDs
A7E2E1
B3KNW7
P51532
Q9HBD4
Q71DI3
PDB IDs
2GRC
2H60
3UVD
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Organization
Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Positive Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Modification
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Organelle Organization
Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Remodeling
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Metabolic Process
Regulation Of Cellular Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Anatomical Structure Development
Developmental Process
Chromatin Assembly Or Disassembly
System Development
Multicellular Organismal Development
ATP-dependent Chromatin Remodeling
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Tagcloud
?
abnormality
arid1a
coinactivation
copyright
fish
frame
harboring
heterozygous
infancy
insights
malignancies
missense
monoploid
mrts
pbrm1
protected
remodeling
reserved
rhabdoid
rights
screened
sense
snf
subunits
swi
trisomy
truncating
Tagcloud (Difference)
?
abnormality
arid1a
coinactivation
copyright
fish
frame
harboring
heterozygous
infancy
insights
malignancies
missense
monoploid
mrts
pbrm1
protected
remodeling
reserved
rhabdoid
rights
screened
sense
snf
subunits
swi
trisomy
truncating
Tagcloud (Intersection)
?