SMARCA4 and GATA1

Number of citations of the paper that reports this interaction (PubMedID 11018012)
56

Data Source:
BioGRID (pull down)

		SMARCA4	GATA1
Description		SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4	GATA binding protein 1
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GO Annotations	Cellular Component	Kinetochore Chromatin Fibrillar Center Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex NpBAF Complex NBAF Complex BBAF Complex GBAF Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding Transcription Coregulator Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Tat Protein Binding Nucleosomal DNA Binding Histone Binding Identical Protein Binding Nuclear Androgen Receptor Binding DNA Polymerase Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase I Preinitiation Complex Assembly Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Heterochromatin Formation Host-mediated Activation Of Viral Transcription Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of G0 To G1 Transition Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Anatomical Structure Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Regulation Of Primitive Erythrocyte Differentiation Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Bone Mineralization Negative Regulation Of Bone Mineralization Animal Organ Regeneration Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Osteoblast Proliferation Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development System Development Erythrocyte Development Homeostasis Of Number Of Cells Within A Tissue Sertoli Cell Development Primitive Erythrocyte Differentiation Platelet Aggregation Cellular Response To Lipopolysaccharide Cellular Response To CAMP Cellular Response To Follicle-stimulating Hormone Stimulus Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Congenital dyserythropoietic anemias (CDAs) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 24262325 32469254 33020668) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Inflammatory skin disease ( 25574825) LDL cholesterol ( 21347282) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 31604244) Total cholesterol levels ( 33339817)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		82 interacting genes: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 ATM BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHFR CHMP5 CIITA CREB1 CTNNB1 E2F6 E4F1 ESR1 ETS2 EZH2 FANCA GATA1 GMNN H2AX H3-3A H3C14 H4C6 HSF1 HSF4 HSPB1 IKZF1 KLF1 MDM2 MED17 MED6 MPHOSPH6 MRTFA MYC MYOCD NR3C1 NR4A2 PABPN1 PALS2 PAX6 PBRM1 PHB1 PTEN RAP1A RASSF1 RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SOX4 SS18 SS18L1 STAT2 STAT3 STK11 SUMO2 TAF15 TMF1 TP53 TTC3 USP7 ZMYND11	86 interacting genes: AKT1 ARID1A ARMC7 ATP6V0D1 BCL6 CASP3 CCDC24 CEBPE CHRD CREBBP DGCR6L DNMT3L FANCG FANCL FBF1 FHL3 FLI1 FRS3 GLRX3 GOLGA2 GRAP2 HDAC3 HDAC4 HDAC5 HEMGN HEXIM2 HEY1 HOXA1 HSPA4 KANK2 KRTAP10-5 KRTAP3-2 KRTAP4-11 KRTAP4-5 KRTAP9-2 LMO2 LZTS2 MAPK1 MAPK3 MAPK6 MDFI MED1 MGAT5B MKRN3 PIAS4 PITX1 PLSCR4 PML PNMA1 PPP1R16B PRKAA1 PRKAB2 PSMF1 RADIL RAI1 RBPMS RIN3 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 TAF7 TAL1 TAX1BP3 TEKT4 TLE5 TNS2 TRAF1 TRIM25 TRIM29 TRIP6 USP7 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		6597	2623
HPRD ID		04459	02372
Ensembl ID		ENSG00000127616	ENSG00000102145
Uniprot IDs		A0A2R8Y7S2 A7E2E1 B3KNW7 P51532 Q9HBD4	P15976
PDB IDs		2GRC 2H60 3UVD 5DKD 5EA1 6BGH 6HR2 6LTH 6LTJ 6SY2 6ZS2 7TAB 7TD9 7VDT 7VDV 7VRB 7Y8R 8EB1 8G1Q 8QJR	6G0Q
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process SWI/SNF Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Process Regulation Of Hemopoiesis Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation NpBAF Complex Regulation Of Cell Development Positive Regulation Of Developmental Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process NpBAF Complex NBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleosome Disassembly Regulation Of G0 To G1 Transition Protein-DNA Complex Disassembly Transcription Coactivator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Brahma Complex RSC-type Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process BBAF Complex Protein Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Lymphocyte Differentiation Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Myoblast Differentiation Nucleoplasm Regulation Of Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of Double-strand Break Repair Regulation Of Myoblast Differentiation Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of T Cell Differentiation Chromatin Remodeling
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