SMARCA4 and CHD4

Number of citations of the paper that reports this interaction (PMID 11003653)
47

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		SMARCA4	CHD4
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	chromodomain helicase DNA binding protein 4
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Microtubule Binding Zinc Ion Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Spindle Assembly
Pathways		Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282)	Myopia (pathological) ( 23049088)
Protein-Protein Interactions		73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11	17 interactors: ATM ATR CSNK2A1 EP300 HDAC1 HIST1H3A HIST3H3 IKZF4 MBD3L2 RBBP7 RNF8 RORC SMARCA4 SUMO1 TRIM27 TWIST1 XRN1
Entrez ID		6597	1108
HPRD ID		04459	04472
Ensembl ID		ENSG00000127616	ENSG00000111642
Uniprot IDs		A7E2E1 B3KNW7 P51532 Q9HBD4	B3KY63 F5GWX5 Q05CG6 Q14839
PDB IDs		2GRC 2H60 3UVD	1MM2 1MM3 2EE1 2L5U 2L75
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Cellular Response To Heat ATP-dependent Chromatin Remodeling Chromosome Organization Regulation Of Viral Transcription DNA Metabolic Process Chromatin Organization Regulation Of Gene Expression, Epigenetic Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Binding RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Heat Regulation Of Cellular Response To Heat Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Rhythmic Process Cellular Metabolic Process Interaction With Symbiont Regulation Of Response To DNA Damage Stimulus Chromatin Modification Regulation Of RNA Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleosome Organization Regulation Of Viral Process Regulation Of Signal Transduction By P53 Class Mediator Histone Modification Transcription, DNA-templated Chromatin Remodeling Regulation Of Metabolic Process RNA Biosynthetic Process Response To Temperature Stimulus
Tagcloud ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified
Tagcloud (Difference) ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	1gamma aromatic caging calixarene calixarenes characterizing chromodomain disrupt finger fingers h3k9me0 h3k9me3 helicase heterochromatin homeodomain hosts hp1gamma macrocyclic nucleosome nurd phd phd2 powerful readers remodelling supramolecular tails trimethylated unmodified
Tagcloud (Intersection) ?