SMARCA4 and STAT2

Number of citations of the paper that reports this interaction (PMID 12244326)
39

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		SMARCA4	STAT2
Gene Name		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	signal transducer and activator of transcription 2, 113kDa
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter JAK-STAT Cascade Viral Process Cytokine-mediated Signaling Pathway Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines	Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282)	Height ( 20881960 23456168) Psoriasis ( 19169254)
Protein-Protein Interactions		73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11	17 interactors: CREBBP CXCR4 EP300 FNTA GAA HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		6597	6773
HPRD ID		04459	02778
Ensembl ID		ENSG00000127616	ENSG00000170581
Uniprot IDs		A7E2E1 B3KNW7 P51532 Q9HBD4	P52630 R9QE65
PDB IDs		2GRC 2H60 3UVD	2KA4
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling	Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Defense Response Cellular Response To Organic Substance Response To Cytokine Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Response To Organic Substance Regulation Of Innate Immune Response Regulation Of Signal Transduction JAK-STAT Cascade Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Response To Stress Regulation Of Androgen Receptor Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Signaling Cell Communication Response To Virus Regulation Of Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated N-terminal Peptidyl-lysine Acetylation Interferon-gamma-mediated Signaling Pathway Interaction With Symbiont Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Autophosphorylation Cellular Response To Interferon-gamma Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Positive Regulation Of Cytokine Production Positive Regulation Of Gene Expression Regulation Of Tubulin Deacetylation Cellular Response To Stimulus Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Response To Interferon-gamma Histone Modification Response To Other Organism Transcription, DNA-templated Response To Biotic Stimulus
Tagcloud ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast
Tagcloud (Difference) ?		abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat5 stat5b stats yeast
Tagcloud (Intersection) ?