SMARCA4 and HSF4

Number of citations: 0 (PubMedID 16552721)
Data Source: BioGRID (affinity chromatography technology, pull down)

		SMARCA4	HSF4
Name		SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4	heat shock transcription factor 4
Structure
GO Annotations	Cellular Component	Kinetochore Chromatin Fibrillar Center Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex NpBAF Complex NBAF Complex BBAF Complex GBAF Complex	Chromatin Nucleus Nuclear Speck
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding Transcription Coregulator Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Tat Protein Binding Nucleosomal DNA Binding Histone Binding Identical Protein Binding Nuclear Androgen Receptor Binding DNA Polymerase Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase I Preinitiation Complex Assembly Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Heterochromatin Formation Host-mediated Activation Of Viral Transcription Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of G0 To G1 Transition Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation
Pathways		Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	None
GWAS		Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Coronary artery disease ( 24262325 32469254 33020668 ) Coronary artery disease or ischemic stroke ( 24262325 ) Coronary artery disease or large artery stroke ( 24262325 ) Disorders of lipid metabolism ( 30166351 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Inflammatory skin disease ( 25574825 ) LDL cholesterol ( 21347282 ) LDL cholesterol levels ( 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Low density lipoprotein cholesterol levels ( 33339817 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Multiple sclerosis ( 31604244 ) Total cholesterol levels ( 33339817 )	No GWAS studies recorded
Interacting Genes		82 interacting genes: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 ATM BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHFR CHMP5 CIITA CREB1 CTNNB1 E2F6 E4F1 ESR1 ETS2 EZH2 FANCA GATA1 GMNN H2AX H3-3A H3C14 H4C6 HSF1 HSF4 HSPB1 IKZF1 KLF1 MDM2 MED17 MED6 MPHOSPH6 MRTFA MYC MYOCD NR3C1 NR4A2 PABPN1 PALS2 PAX6 PBRM1 PHB1 PTEN RAP1A RASSF1 RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SOX4 SS18 SS18L1 STAT2 STAT3 STK11 SUMO2 TAF15 TMF1 TP53 TTC3 USP7 ZMYND11	43 interacting genes: ACTMAP AKAP8L ALKBH4 C10orf55 CDK2AP2 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZMYND12
Entrez ID		6597	3299
HPRD ID		04459	03896
Ensembl ID		ENSG00000127616	ENSG00000102878
Uniprot IDs		A0A2R8Y7S2 A7E2E1 B3KNW7 P51532 Q9HBD4	Q9ULV5
PDB IDs		2GRC 2H60 3UVD 5DKD 5EA1 6BGH 6HR2 6LTH 6LTJ 6SY2 6ZS2 7TAB 7TD9 7VDT 7VDV 7VRB 7Y8R 8EB1 8G1Q 8QJR	6J6V 6J6W
GO Terms Enriched among Interactors		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process SWI/SNF Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Process Regulation Of Hemopoiesis Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation NpBAF Complex Regulation Of Cell Development Positive Regulation Of Developmental Process	Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport