SMARCA4 and MYC

Number of citations: 55 (PubMedID 28205554)
Data Source: BioGRID (fluorescent resonance energy transfer, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)

		SMARCA4	MYC
Name		SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4	MYC proto-oncogene, bHLH transcription factor
Structure
GO Annotations	Cellular Component	Kinetochore Chromatin Fibrillar Center Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex NpBAF Complex NBAF Complex BBAF Complex GBAF Complex	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Nuclear Body Axon Protein-containing Complex Perinuclear Region Of Cytoplasm Myc-Max Complex RNA Polymerase II Transcription Repressor Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding Transcription Coregulator Binding P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Tat Protein Binding Nucleosomal DNA Binding Histone Binding Identical Protein Binding Nuclear Androgen Receptor Binding DNA Polymerase Binding ATP-dependent Chromatin Remodeler Activity Nucleosome Array Spacer Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding SCF Ubiquitin Ligase Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase I Preinitiation Complex Assembly Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Heterochromatin Formation Host-mediated Activation Of Viral Transcription Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of G0 To G1 Transition Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis B Cell Apoptotic Process NK T Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of B Cell Apoptotic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis DNA Damage Response Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Xenobiotic Stimulus Regulation Of Gene Expression Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Myotube Differentiation Wnt Signaling Pathway RRNA Metabolic Process Protein Processing Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Protein-DNA Complex Disassembly Cellular Response To UV Cellular Response To Interferon-alpha Skeletal Muscle Cell Differentiation Middle Ear Morphogenesis Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Alkaloid Pigmentation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Skeletal System Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chromosome Organization Negative Regulation Of Cell Division Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Transcription Initiation By RNA Polymerase II ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of MiRNA Transcription Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Acinar Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Transcription of E2F targets under negative control by DREAM complex Signaling by ALK NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Regulation of CDH1 mRNA translation by microRNAs Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription
Drugs		None	Acetylsalicylic acid Dimethyl sulfoxide Doconexent Nadroparin
Diseases		None	Penile cancer Breast cancer Laryngeal cancer Oral cancer Multiple myeloma Kaposi's sarcoma Ovarian cancer Choriocarcinoma Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Burkitt lymphoma Small cell lung cancer Osteosarcoma Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Adult body size ( 32376654 ) Apolipoprotein B levels ( 32203549 ) Coronary artery disease ( 24262325 32469254 33020668 ) Coronary artery disease or ischemic stroke ( 24262325 ) Coronary artery disease or large artery stroke ( 24262325 ) Disorders of lipid metabolism ( 30166351 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Inflammatory skin disease ( 25574825 ) LDL cholesterol ( 21347282 ) LDL cholesterol levels ( 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Low density lipoprotein cholesterol levels ( 33339817 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Multiple sclerosis ( 31604244 ) Total cholesterol levels ( 33339817 )	Alcohol use disorder ( 30940813 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 23817571 ) Asthma ( 34103634 32296059 30929738 ) Asthma (childhood onset) ( 31036433 30929738 ) Bladder cancer ( 20972438 ) Breast cancer ( 29059683 23535729 ) Chronic lymphocytic leukemia ( 23770605 ) Colorectal cancer ( 24737748 25990418 26151821 23266556 ) Colorectal cancer or advanced adenoma ( 30510241 ) Diffuse large B cell lymphoma ( 25261932 ) Endometrial cancer ( 30093612 27135401 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometrial endometrioid carcinoma ( 27135401 ) Glioblastoma ( 29743610 ) Glioma ( 29743610 ) Height ( 25429064 ) Multiple sclerosis ( 21833088 ) Non-glioblastoma glioma ( 29743610 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Ovarian cancer ( 20852632 23535730 ) Pancreatic cancer ( 27579533 29422604 25086665 ) Prostate cancer ( 24753544 ) Prostate cancer (early onset) ( 24740154 ) Prostate-specific antigen levels ( 28139693 ) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693 ) Renal cell carcinoma ( 24220699 ) Serum alkaline phosphatase levels ( 33547301 ) Urinary bladder cancer ( 24861552 18794855 20348956 )
Novel Interactors		11 novel interactors: CCL25 CYP4F3 HMGCL ICAM5 NPPB PDE4A PRKCSH RAD23A RPS28 VAV1 ZNF69	None recorded
Interacting Genes		82 interacting genes: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 ATM BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHFR CHMP5 CIITA CREB1 CTNNB1 E2F6 E4F1 ESR1 ETS2 EZH2 FANCA GATA1 GMNN H2AX H3-3A H3C14 H4C6 HSF1 HSF4 HSPB1 IKZF1 KLF1 MDM2 MED17 MED6 MPHOSPH6 MRTFA MYC MYOCD NR3C1 NR4A2 PABPN1 PALS2 PAX6 PBRM1 PHB1 PTEN RAP1A RASSF1 RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SOX4 SS18 SS18L1 STAT2 STAT3 STK11 SUMO2 TAF15 TMF1 TP53 TTC3 USP7 ZMYND11	182 interacting genes: ACTL6A AKT1 APP ARAF ARNT ATAD2 ATG5 AURKA AXIN1 BCL2 BIN1 BRCA1 BRD3 CBLC CCAR2 CCNE1 CCNT1 CDC6 CDC73 CDCA7L CDK1 CDK6 CDK8 CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CEBPB CEP57 CHD8 CHUK CIP2A CREBBP CSNK2A1 CSNK2A2 DACH1 DNMT3A EFNB1 ELF3 ELP3 EP300 EP400 EPHA2 ERBB2 FBXO32 FBXO8 FBXW7 FBXW8 FGFR4 FZR1 GCN1 GLIS1 GLIS2 GPX2 GRM1 GSK3A GSK3B GTF2F1 GTF2I HIF1A HNRNPD HSP90AA1 IKBKB ING4 KAT2A KAT2B KAT5 KDELR2 KDM1A KIDINS220 LATS2 LDOC1 MAP2K1 MAP2K5 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAX MDM2 MED1 MED16 MEN1 MET MLH1 MOK MXD1 MXI1 MYCBP MYCBP2 NDRG1 NEK11 NF2 NFIC NFYB NFYC NMI NONO NOTCH3 NUCB1 OTUB1 PAK2 PARP10 PCGF6 PDGFRA PFDN5 PIK3CA PLAU PLK1 PML PPP2CA PPP3R1 PRDX1 PSMC3 PTEN RAF1 RASSF1 RB1 RBL1 RELA RIOX2 SAP130 SENP2 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SOX3 SOX4 SP1 SPAG9 STK11 SUPT3H TADA2A TAF12 TAF1B TAF9 TBP TEAD2 TERT TFAP2A TFAP2B TIAM1 TONSL TP53 TP73 TRIB3 TRIM6 TRIM63 TRIP12 TRRAP TSC1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB UBE3B UBR5 USP1 USP2 USP36 USP37 USP45 USP7 VDR WT1 YAF2 YBX1 YY1 ZBTB17 ZNF281
Entrez ID		6597	4609
HPRD ID		04459	01818
Ensembl ID		ENSG00000127616	ENSG00000136997
Uniprot IDs		A0A2R8Y7S2 A7E2E1 B3KNW7 P51532 Q9HBD4	P01106
PDB IDs		2GRC 2H60 3UVD 5DKD 5EA1 6BGH 6HR2 6LTH 6LTJ 6SY2 6ZS2 7TAB 7TD9 7VDT 7VDV 7VRB 7Y8R 8EB1 8G1Q 8QJR	1A93 1EE4 1MV0 1NKP 2A93 2OR9 4Y7R 5I4Z 5I50 6C4U 6E16 6E24 6G6J 6G6K 6G6L 7T1Y 7T1Z 8J2Q 8OTS 8OTT 8Q1N 8WLG 8X8S 8X8V
GO Terms Enriched among Interactors		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process SWI/SNF Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Process Regulation Of Hemopoiesis Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation NpBAF Complex Regulation Of Cell Development Positive Regulation Of Developmental Process	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Cellular Response To Stress Regulation Of Cellular Response To Stress Regulation Of DNA Metabolic Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Apoptotic Process DNA-binding Transcription Factor Binding Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Cell Differentiation Chromatin Organization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Protein Modification Process Regulation Of Protein Modification Process Chromatin Binding