SLC2A1 and COPS6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC2A1	COPS6
Gene Name		solute carrier family 2 (facilitated glucose transporter), member 1	COP9 signalosome subunit 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Female Pronucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Midbody Cortical Actin Cytoskeleton Melanosome Extracellular Vesicular Exosome Blood Microparticle	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Kinase Binding Dehydroascorbic Acid Transporter Activity Identical Protein Binding Xenobiotic Transporter Activity Protein Self-association D-glucose Transmembrane Transporter Activity	Protein Binding
	Biological Process	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Protein Complex Assembly Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Response To Osmotic Stress Hexose Transport Pathogenesis Glucose Transport L-ascorbic Acid Metabolic Process Cellular Response To Glucose Starvation Xenobiotic Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Dehydroascorbic Acid Transport	Cullin Deneddylation Viral Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG SLC-mediated transmembrane transport Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Myoclonic epilepsy of Lafora Glycogen storage diseases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Regulation of insulin secretion Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Hexose transport Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Metabolism of carbohydrates Glucose transport Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		11 interactors: CALR CANX COPS6 GAPDH GIPC1 PDIA3 PTK2B STOM SUMO1 UBE2I VHL	84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24
Entrez ID		6513	10980
HPRD ID		00683	16735
Ensembl ID		ENSG00000117394	ENSG00000168090
Uniprot IDs		P11166 Q59GX2	Q7L5N1
PDB IDs		1SUK
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Protein Stability Cellular Protein Modification Process Posttranscriptional Regulation Of Gene Expression Protein Stabilization Cellular Protein Metabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Protein Sumoylation Response To Lithium Ion Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cellular Metabolic Process Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Translation Protein Folding Antigen Processing And Presentation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chaperone-mediated Protein Folding Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of Leukocyte Chemotaxis Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of SUMO Transferase Activity Regulation Of Acid-sensing Ion Channel Activity Endothelial Cell Migration Regulation Of Protein Catabolic Process Glycoprotein Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Migration Negative Regulation Of Translation Epithelial Cell Migration Epithelium Migration Carbohydrate Metabolic Process Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Glycoprotein Metabolic Process Protein Localization Positive Regulation Of Chemotaxis Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent	Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death
Tagcloud ?		atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc37a4 washings	aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Difference) ?		atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc37a4 washings	aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Intersection) ?