SLC2A1 and GPR35

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		SLC2A1	GPR35
Name		solute carrier family 2 member 1	G protein-coupled receptor 35
Structure
GO Annotations	Cellular Component	Golgi Membrane Female Germ Cell Nucleus Photoreceptor Inner Segment Female Pronucleus Cytoplasm Cytosol Plasma Membrane Caveola Cell-cell Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Vesicle Sarcolemma Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Presynapse Glucose Transporter Complex	Plasma Membrane Membrane
	Molecular Function	Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding Fucose Transmembrane Transporter Activity Kinase Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Response To Hypoxia Central Nervous System Development Female Pregnancy Fucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance D-glucose Import Transmembrane Transport Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine D-glucose Transmembrane Transport	Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis	Class A/1 (Rhodopsin-like receptors)
Drugs		Resveratrol Carboxymethylcellulose	Furosemide Pyrantel Kynurenic Acid
Diseases		GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)	None
GWAS		Birth weight ( 31043758 ) Cardiac hypertrophy ( 21348951 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) White blood cell count ( 32888494 )	Ankylosing spondylitis ( 23749187 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 25489960 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Inflammatory bowel disease ( 23128233 28067908 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403 ) Ulcerative colitis ( 21297633 28067908 )
Interacting Genes		18 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 TXNIP UBE2I USP2 VHL WWP1	58 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		6513	2859
HPRD ID		00683	16003
Ensembl ID		ENSG00000117394	ENSG00000178623
Uniprot IDs		P11166 Q59GX2	A8K2J1 B2RA17 Q9HC97
PDB IDs		4PYP 5EQG 5EQH 5EQI 6THA	8H8J
GO Terms Enriched among Interactors		Protein Folding In Endoplasmic Reticulum Perinuclear Region Of Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Protein Stability Small Protein Activating Enzyme Binding Protein Stabilization MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Catalytic Activity Protein Modification Process Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cell Communication Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-7 Response To Interleukin-7 Post-translational Protein Modification Protein Folding Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Transcription Factor Binding Positive Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transport Chemokine Receptor Activity Protein Modification By Small Protein Conjugation Endoplasmic Reticulum Quality Control Compartment Negative Regulation Of RNA Biosynthetic Process Regulation Of Lymphocyte Chemotaxis Unfolded Protein Binding Negative Regulation Of Transporter Activity Protein Metabolic Process Presynaptic Cytosol Peptide Binding Postsynaptic Cytosol Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Membrane Inorganic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transport Monoatomic Ion Transport Membrane Organization Cholesterol Metabolic Process Metal Ion Transport Sterol Metabolic Process Inorganic Cation Transmembrane Transport Regulation Of Toll-like Receptor 9 Signaling Pathway Monoatomic Cation Transmembrane Transport Import Across Plasma Membrane Sterol Biosynthetic Process Positive Regulation Of Protein Localization Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Cytoplasmic Vesicle Membrane Plasma Membrane Lysosome Glucose 6-phosphate:phosphate Antiporter Activity C-4 Methylsterol Oxidase Activity Lysosomal Membrane Import Into Cell Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Chemical Homeostasis Intracellular Monoatomic Ion Homeostasis Vesicle-mediated Transport Recycling Endosome Glucose-6-phosphate Transport Phagocytic Cup Carbohydrate Derivative Transport Steroid Metabolic Process Potassium Ion Transmembrane Transport Endoplasmic Reticulum Tubular Network Formation Late Endosome Membrane Monoatomic Cation Homeostasis Regulation Of Protein Localization Steroid Biosynthetic Process Monoatomic Ion Homeostasis Postsynaptic Density Proton Transmembrane Transport Cholesterol Biosynthetic Process Positive Regulation Of Intracellular Protein Transport