SLC2A1 and GCN1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology)

		SLC2A1	GCN1
Name		solute carrier family 2 member 1	GCN1 activator of EIF2AK4
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Female Germ Cell Nucleus Photoreceptor Inner Segment Female Pronucleus Cytoplasm Cytosol Plasma Membrane Caveola Cell-cell Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Vesicle Sarcolemma Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Presynapse Glucose Transporter Complex	Cytoplasm Cytosol Ribosome Membrane Cytosolic Ribosome
	Molecular Function	Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding Fucose Transmembrane Transporter Activity Kinase Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	RNA Binding Translation Factor Activity, RNA Binding Protein Kinase Regulator Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ubiquitin-protein Transferase Regulator Activity Molecular Adaptor Activity Stalled Ribosome Sensor Activity
	Biological Process	Response To Hypoxia Central Nervous System Development Female Pregnancy Fucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance D-glucose Import Transmembrane Transport Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine D-glucose Transmembrane Transport	Translational Elongation Regulation Of Translation Ubiquitin-dependent Protein Catabolic Process Cellular Response To Amino Acid Starvation Rescue Of Stalled Ribosome Protein K6-linked Ubiquitination GCN2-mediated Signaling Protein-RNA Covalent Cross-linking Repair
Pathways		Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis	Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs		Resveratrol Carboxymethylcellulose	None
Diseases		GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)	None
GWAS		Birth weight ( 31043758 ) Cardiac hypertrophy ( 21348951 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) White blood cell count ( 32888494 )	Appendicular lean mass ( 33097823 )
Novel Interactors		9 novel interactors: ADNP BMP8B CDKN1C CHRNB4 FAAH GCN1 PTPRU SMAP2 ZRSR2	1 novel interactors: SLC2A1
Interacting Genes		18 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 TXNIP UBE2I USP2 VHL WWP1	4 interacting genes: MYC RNF10 SUMO2 YWHAQ
Entrez ID		6513	10985
HPRD ID		00683	16127
Ensembl ID		ENSG00000117394	ENSG00000089154
Uniprot IDs		P11166 Q59GX2	Q92616
PDB IDs		4PYP 5EQG 5EQH 5EQI 6THA	Not available
GO Terms Enriched among Interactors		Protein Folding In Endoplasmic Reticulum Perinuclear Region Of Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Protein Stability Small Protein Activating Enzyme Binding Protein Stabilization MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Catalytic Activity Protein Modification Process Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cell Communication Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-7 Response To Interleukin-7 Post-translational Protein Modification Protein Folding Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Transcription Factor Binding Positive Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transport Chemokine Receptor Activity Protein Modification By Small Protein Conjugation Endoplasmic Reticulum Quality Control Compartment Negative Regulation Of RNA Biosynthetic Process Regulation Of Lymphocyte Chemotaxis Unfolded Protein Binding Negative Regulation Of Transporter Activity Protein Metabolic Process Presynaptic Cytosol Peptide Binding Postsynaptic Cytosol Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic	Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Glucose Transporter Complex Myc-Max Complex Regulation Of Acinar Cell Proliferation Fucose Transmembrane Transporter Activity Fucose Transmembrane Transport RNA Polymerase II Transcription Repressor Complex Negative Regulation Of DNA-templated Transcription Initiation NK T Cell Proliferation Ubiquitin Protein Ligase Binding Positive Regulation Of Kidney Development Regulation Of Somatic Stem Cell Population Maintenance Response To Decreased Oxygen Levels Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation Response To Hypoxia Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Fibroblast Apoptotic Process NK T Cell Activation Negative Regulation Of Cell Development Cellular Response To Interferon-alpha Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Mechanical Stimulus Positive Regulation Of Cell Proliferation Involved In Kidney Development Positive Regulation Of B Cell Apoptotic Process B Cell Apoptotic Process Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II D-glucose Transmembrane Transporter Activity L-ascorbic Acid Metabolic Process Response To Thyroglobulin Triiodothyronine Dehydroascorbic Acid Transport Presynapse D-glucose Import Across Plasma Membrane Long-chain Fatty Acid Import Across Plasma Membrane Dehydroascorbic Acid Transmembrane Transporter Activity Long-chain Fatty Acid Import Into Cell Female Pronucleus Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Extrinsic Component Of Postsynaptic Density Membrane Response To Oxygen Levels Female Germ Cell Nucleus Alpha-beta T Cell Proliferation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation