COPS6 and MAP3K1

Number of citations of the paper that reports this interaction (PubMedID 26237449)
55

Data Source:
BioGRID (pull down)

		COPS6	MAP3K1
Description		COP9 signalosome subunit 6	mitogen-activated protein kinase kinase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Tight Junction
	Molecular Function	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation	MAPK Cascade Protein Phosphorylation Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs			AZD-8330 Binimetinib Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 19330030 20453838 29059683 23535729 17529967 31757997) Breast cancer (early onset) ( 24493630) Brown vs. black hair color ( 30531825) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Fasting blood insulin ( 25631608) Fasting glucose in pregnancy (gestational week 14-16) ( 30324795) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Initial pursuit acceleration ( 29064472) Lung function (FEV1) ( 30061609) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Sexual dimorphism in anthropometric traits ( 23754948) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32902719 28334899) Triglycerides ( 20686565 24097068) Type 2 diabetes ( 23209189) Urate levels (BMI interaction) ( 25811787) Waist circumference ( 23966867) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	94 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHRM5 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1L2 TP53 TRAF2 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 ZFAND3 ZFAND5
Entrez ID		10980	4214
HPRD ID		16735	19599
Ensembl ID		ENSG00000168090	ENSG00000095015
Uniprot IDs		Q7L5N1	Q13233
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	6WHB
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling	Ubiquitin Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytosol Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin Protein Ligase Binding Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Catabolic Process Protein Polyubiquitination Proteolysis Positive Regulation Of Protein Modification Process Protein Ubiquitination Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Modification Process Cytoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Metabolic Process Transferase Activity Regulation Of Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Macromolecule Metabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Signal Transduction VCP-NPL4-UFD1 AAA ATPase Complex Protein K48-linked Ubiquitination Nucleoplasm ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Intracellular Protein Transport Protein Transport Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Identical Protein Binding Regulation Of Intracellular Signal Transduction Intracellular Protein Localization Non-canonical NF-kappaB Signal Transduction DNA Repair Regulation Of Immune Response Regulation Of Post-translational Protein Modification
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