SLC2A1 and CALR

Number of citations of the paper that reports this interaction (PMID 8662691)
8

Data Source:
HPRD (in vivo)

		SLC2A1	CALR
Gene Name		solute carrier family 2 (facilitated glucose transporter), member 1	calreticulin
Image
Gene Ontology Annotations	Cellular Component	Female Pronucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Midbody Cortical Actin Cytoskeleton Melanosome Extracellular Vesicular Exosome Blood Microparticle	Acrosomal Vesicle Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Sarcoplasmic Reticulum Lumen MHC Class I Peptide Loading Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding Kinase Binding Dehydroascorbic Acid Transporter Activity Identical Protein Binding Xenobiotic Transporter Activity Protein Self-association D-glucose Transmembrane Transporter Activity	Complement Component C1q Binding Glycoprotein Binding DNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Poly(A) RNA Binding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Carbohydrate Metabolic Process Energy Reserve Metabolic Process Protein Complex Assembly Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Response To Osmotic Stress Hexose Transport Pathogenesis Glucose Transport L-ascorbic Acid Metabolic Process Cellular Response To Glucose Starvation Xenobiotic Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Transmembrane Transport Dehydroascorbic Acid Transport	Negative Regulation Of Transcription From RNA Polymerase II Promoter Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein N-linked Glycosylation Via Asparagine Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Regulation Of Meiosis Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Chaperone-mediated Protein Folding Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Integration of energy metabolism Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG SLC-mediated transmembrane transport Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Myoclonic epilepsy of Lafora Glycogen storage diseases Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Regulation of insulin secretion Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Hexose transport Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Metabolism of carbohydrates Glucose transport Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Scavenging by Class F Receptors Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Scavenging by Class A Receptors Assembly of Viral Components at the Budding Site ATF6-alpha activates chaperones Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ATF6-alpha activates chaperone genes Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Red blood cell traits ( 23222517)
Protein-Protein Interactions		11 interactors: CALR CANX COPS6 GAPDH GIPC1 PDIA3 PTK2B STOM SUMO1 UBE2I VHL	39 interactors: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 SCARF1 SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TSHR UPF2 VWF
Entrez ID		6513	811
HPRD ID		00683	00169
Ensembl ID		ENSG00000117394	ENSG00000179218
Uniprot IDs		P11166 Q59GX2	P27797
PDB IDs		1SUK	2CLR 3DOW 3POS 3POW
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Peptidyl-amino Acid Modification Regulation Of Protein Stability Cellular Protein Modification Process Posttranscriptional Regulation Of Gene Expression Protein Stabilization Cellular Protein Metabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Protein Sumoylation Response To Lithium Ion Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cellular Metabolic Process Immune System Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Translation Protein Folding Antigen Processing And Presentation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chaperone-mediated Protein Folding Protein Glycosylation Macromolecule Glycosylation Positive Regulation Of Leukocyte Chemotaxis Glycosylation Peptide Antigen Assembly With MHC Class I Protein Complex Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of SUMO Transferase Activity Regulation Of Acid-sensing Ion Channel Activity Endothelial Cell Migration Regulation Of Protein Catabolic Process Glycoprotein Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Migration Negative Regulation Of Translation Epithelial Cell Migration Epithelium Migration Carbohydrate Metabolic Process Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Glycoprotein Metabolic Process Protein Localization Positive Regulation Of Chemotaxis Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent	Response To Stimulus Response To Stress Platelet Degranulation Blood Coagulation Hemostasis Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Wound Healing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cell Activation Response To Wounding Platelet Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Exocytosis Response To External Stimulus Cellular Response To Stimulus Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I System Development Secretion By Cell Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Cell Communication Immune Response Behavior Positive Regulation Of Leukocyte Mediated Cytotoxicity Transport Secretion Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Protection From Natural Killer Cell Mediated Cytotoxicity Signaling Multicellular Organismal Development Signal Transduction Negative Regulation Of Signaling Cell Adhesion Response To Hormone Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Anatomical Structure Development Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Organic Substance
Tagcloud ?		atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc37a4 washings	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Difference) ?		atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc37a4 washings	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
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