COPS6 and PFKL

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	PFKL
Gene Name		COP9 signalosome subunit 6	phosphofructokinase, liver
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome	Cytosol 6-phosphofructokinase Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Cullin Deneddylation Viral Process	Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Carbohydrate Phosphorylation Protein Oligomerization Protein Homotetramerization
Pathways			Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS			Rheumatoid arthritis ( 21505073)
Protein-Protein Interactions		84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24	12 interactors: APP ATN1 COPS6 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PFKM PRPF40A TESK1 YWHAQ
Entrez ID		10980	5211
HPRD ID		16735	01385
Ensembl ID		ENSG00000168090	ENSG00000141959
Uniprot IDs		Q7L5N1	P17858 Q7L2M7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	aerobic ambiguous biogenesis biomass cd147 contributed differing export facilitated finger glut1 glycolysis glycoprotein hcc lactate mct1 mediators metabolism nuclease p53r2 pgc1alpha reprogrammed reprogramming rnai supplies systematically tfam transmembrane warburg
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	aerobic ambiguous biogenesis biomass cd147 contributed differing export facilitated finger glut1 glycolysis glycoprotein hcc lactate mct1 mediators metabolism nuclease p53r2 pgc1alpha reprogrammed reprogramming rnai supplies systematically tfam transmembrane warburg
Tagcloud (Intersection) ?