SLC2A1 and ADNP

Data Source: HiPPIP (Novel)

		SLC2A1	ADNP
Name		solute carrier family 2 member 1	activity dependent neuroprotector homeobox
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Female Germ Cell Nucleus Photoreceptor Inner Segment Female Pronucleus Cytoplasm Cytosol Plasma Membrane Caveola Cell-cell Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Vesicle Sarcolemma Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Presynapse Glucose Transporter Complex	Chromatin Extracellular Space Nucleus Chromosome Axon Dendrite Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding Fucose Transmembrane Transporter Activity Kinase Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Copper Ion Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Peptide Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Response To Hypoxia Central Nervous System Development Female Pregnancy Fucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance D-glucose Import Transmembrane Transport Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine D-glucose Transmembrane Transport	Regulation Of Transcription By RNA Polymerase II Short-term Memory Response To Carbohydrate Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development CGMP-mediated Signaling Neuron Differentiation Intracellular Nitric Oxide Homeostasis Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of Axon Extension Negative Regulation Of Synaptic Transmission Neuron Apoptotic Process Positive Regulation Of Synapse Assembly Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis	None
Drugs		Resveratrol Carboxymethylcellulose	None
Diseases		GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)	None
GWAS		Birth weight ( 31043758 ) Cardiac hypertrophy ( 21348951 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) White blood cell count ( 32888494 )	Prostate cancer ( 25217961 )
Novel Interactors		9 novel interactors: ADNP BMP8B CDKN1C CHRNB4 FAAH GCN1 PTPRU SMAP2 ZRSR2	1 novel interactors: SLC2A1
Interacting Genes		18 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 TXNIP UBE2I USP2 VHL WWP1	4 interacting genes: CDC27 H3-4 KPNA4 MAP1LC3B
Entrez ID		6513	23394
HPRD ID		00683	09793
Ensembl ID		ENSG00000117394	ENSG00000101126
Uniprot IDs		P11166 Q59GX2	A0A2R8Y6X0 A0A669KBJ7 Q6DHZ8 Q9H2P0
PDB IDs		4PYP 5EQG 5EQH 5EQI 6THA	Not available
GO Terms Enriched among Interactors		Protein Folding In Endoplasmic Reticulum Perinuclear Region Of Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Protein Stability Small Protein Activating Enzyme Binding Protein Stabilization MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Catalytic Activity Protein Modification Process Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cell Communication Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-7 Response To Interleukin-7 Post-translational Protein Modification Protein Folding Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Transcription Factor Binding Positive Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transport Chemokine Receptor Activity Protein Modification By Small Protein Conjugation Endoplasmic Reticulum Quality Control Compartment Negative Regulation Of RNA Biosynthetic Process Regulation Of Lymphocyte Chemotaxis Unfolded Protein Binding Negative Regulation Of Transporter Activity Protein Metabolic Process Presynaptic Cytosol Peptide Binding Postsynaptic Cytosol Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic	Metaphase/anaphase Transition Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Dopamine Secretion Catecholamine Secretion NLS-dependent Protein Nuclear Import Complex D-glucose Transmembrane Transporter Activity L-ascorbic Acid Metabolic Process Response To Thyroglobulin Triiodothyronine Cellular Response To Starvation Fucose Transmembrane Transporter Activity Dehydroascorbic Acid Transport D-glucose Import Across Plasma Membrane Response To Starvation Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Nutrient Levels Glucose Transporter Complex Dehydroascorbic Acid Transmembrane Transporter Activity Fucose Transmembrane Transport Female Pronucleus DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Cellular Response To Nitrogen Starvation Ceramide Binding Long-chain Fatty Acid Import Into Cell Lipid Import Into Cell Female Germ Cell Nucleus Phosphatidylethanolamine Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein-containing Complex Organization Anaphase-promoting Complex-dependent Catabolic Process Protein Branched Polyubiquitination Cell Division Anaphase-promoting Complex Positive Regulation Of Hippo Signaling Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Dopamine Transport Cellular Hyperosmotic Response D-glucose Import Xenobiotic Transmembrane Transporter Activity NLS-bearing Protein Import Into Nucleus Response To Nutrient Levels Hyperosmotic Response D-glucose Transmembrane Transport Monoamine Transport