COPS6 and PBX2

Number of citations of the paper that reports this interaction (PubMedID 14667819)
0

Data Source:
HPRD (two hybrid)

		COPS6	PBX2
Description		COP9 signalosome subunit 6	PBX homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation	Eye Development Regulation Of DNA-templated Transcription Brain Development Animal Organ Morphogenesis Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Advanced age-related macular degeneration ( 26691988) Anxiety ( 33859377) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Coronary artery disease ( 33020668) Crohn's disease ( 23266558) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Refractive error ( 32231278) Rheumatic heart disease ( 32488134) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	38 interacting genes: BAIAP2 BFSP2 BLOC1S1 BLOC1S5 BRMS1L CARD9 CCDC88B CDCA7L CENPBD1P COPS6 DCTN3 EFHC1 ELP1 FAM90A1 HOXA1 HOXA5 HOXA9 HOXB5 HOXB8 HOXC5 HOXC8 HOXC9 MCRS1 MSC MTREX NUP62 PBX1 PKNOX1 PPFIBP1 RIPPLY2 RPL4 RPS6KC1 SMYD3 TTC3 UBE2E1 ZCWPW2 ZDHHC7 ZNF587
Entrez ID		10980	5089
HPRD ID		16735	08890
Ensembl ID		ENSG00000168090	ENSG00000204304
Uniprot IDs		Q7L5N1	A0A024RCR3 P40425
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling	Anterior/posterior Pattern Specification Embryonic Skeletal System Development Regionalization DNA-binding Transcription Factor Activity Pattern Specification Process Skeletal System Morphogenesis Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Embryonic Morphogenesis Skeletal System Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Embryonic Organ Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Animal Organ Morphogenesis Proximal/distal Pattern Formation Nucleoplasm Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II BLOC-1 Complex Anterograde Synaptic Vesicle Transport DNA Binding Hemopoiesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation
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