COPS6 and STK40

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	STK40
Description		COP9 signalosome subunit 6	serine/threonine kinase 40
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation	Respiratory System Process Glycogen Metabolic Process Regulation Of Gene Expression Lung Development Multicellular Organism Growth Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Neutrophil count ( 32888494)
Interacting Genes		95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	6 interacting genes: APP COPS6 LRRK2 NEDD4L POLA2 SLIRP
Entrez ID		10980	83931
HPRD ID		16735	11359
Ensembl ID		ENSG00000168090	ENSG00000196182
Uniprot IDs		Q7L5N1	Q8N2I9
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	5L2Q
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling	Golgi-associated Vesicle Positive Regulation Of Endocytosis Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Neuromuscular Junction Development Synapse Organization Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Macromolecule Metabolic Process Regulation Of Synapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Membrane Depolarization Regulation Of Endocytosis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Acetylcholine Receptor Activator Activity Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Membrane Potential Regulation Of Response To Endoplasmic Reticulum Stress Endocytosis Regulation Of Calcium-mediated Signaling Lipoprotein Particle Cell Junction Organization Positive Regulation Of Protein Import Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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