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COPS6 and NEDD8
Number of citations of the paper that reports this interaction (PubMedID
34642328
)
74
Data Source:
BioGRID
(pull down, pull down)
COPS6
NEDD8
Description
COP9 signalosome subunit 6
NEDD8 ubiquitin like modifier
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
COP9 Signalosome
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Binding
Peptidase Activity
Metal-dependent Deubiquitinase Activity
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Biological Process
Protein Deneddylation
Protein Neddylation
Regulation Of Protein Neddylation
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Intracellular Protein Localization
Anatomical Structure Morphogenesis
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Regulation Of Proteolysis
Protein Modification Process
Protein Neddylation
Cellular Response To Camptothecin
Regulation Of Postsynapse Assembly
Pathways
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Mean corpuscular volume (
29403010
)
Systolic blood pressure (cigarette smoking interaction) (
26752167
)
Interacting Genes
95 interacting genes:
ANXA1
ANXA7
ASH2L
BFSP2
BTBD2
C1orf174
C4orf17
CASP3
CASP6
CASP7
CASP8
CCBE1
CCDC106
CDH10
CDKN1A
CDKN2C
CHRNB1
COPS2
COPS3
COPS4
COPS5
COPS8
COX17
COX5A
CRELD1
CRIPTO
CUL1
CUL5
DIS3L2
DLEU1
DSP
EDN1
EIF3E
EMD
EP300
ERH
FAU
GPS1
HMOX2
LAMA4
LPL
MAP3K1
MAP7D1
MAPK1
MAPK6
MAPKAPK3
MIF
MNAT1
MYCBP
NEDD8
NR3C1
ORAI2
PAEP
PAFAH1B3
PBX2
PDZK1IP1
PFKL
PHYHIP
PMF1
PRKRA
PSAP
PSMD11
PTEN
QTRT1
RAB27A
RBX1
RFC5
ROGDI
RPA2
RPL15
S100A10
SAT1
SERPINA5
SERPINB9
SHANK3
SHC3
SLC2A1
SMN1
SNRPG
STAMBPL1
STK40
STX5
SULT1E1
TK1
TP53
TP63
TRDMT1
TRIB3
UBC
USHBP1
VIM
WIPI2
ZEB2
ZFHX3
ZNF24
71 interacting genes:
AHR
ANKRD13D
ARIH2
ATXN3
BAG3
CBLB
CDC34
COPS5
COPS6
CTRC
CUL1
CUL2
CUL3
CUL4B
DNAJA2
DNAJB2
DNMT3B
EIF3I
FAF1
GARS1
GHR
GRN
GTF3C3
HDAC6
HGS
HIF1A
HSPA1B
HSPA4
HSPA4L
HSPA8
HSPA9
HSPH1
HYPK
KLHDC2
N4BP1
NAE1
NSFL1C
NUB1
NXPH2
OLFML2B
OTUB1
OTUB2
OTUD5
OTUD6B
PARP1
PCNA
POLI
PPP1CA
PRKN
PSMA6
PSMD4
PTK2
RAD23A
SENP8
SET
SIRT1
SMURF1
SQSTM1
TOLLIP
TP53
TUBB4B
UBA2
UBA3
UBE2K
UBE2M
UBL7
UBQLN1
UBXN7
UCHL1
UCHL3
YAF2
Entrez ID
10980
4738
HPRD ID
16735
04412
Ensembl ID
ENSG00000168090
ENSG00000129559
Uniprot IDs
Q7L5N1
Q15843
PDB IDs
4D10
4D18
4QFT
4R14
4WSN
6R6H
6R7F
6R7H
6R7I
8H38
8H3A
8H3F
1NDD
1R4M
1R4N
1XT9
2BKR
2KO3
2N7K
2NVU
3DBH
3DBL
3DBR
3DQV
3GZN
4F8C
4FBJ
4HCP
4P5O
6R7F
6R7I
6TTU
7B5L
7B5N
7ONI
8B3G
8B3I
8CAF
8H38
8Q7H
8RX0
8WQC
8WQG
8WZN
8WZO
Enriched GO Terms of Interacting Partners
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Protein Neddylation
Protein Deneddylation
Regulation Of Protein Neddylation
Nucleoplasm
Heart Development
COP9 Signalosome
Developmental Process
Cytosol
Cellular Response To Staurosporine
Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
Ubiquitin Protein Ligase Binding
Signal Transduction By P53 Class Mediator
Cellular Response To Nutrient Levels
Protein Binding
Positive Regulation Of Neuron Apoptotic Process
Protease Binding
Pyroptotic Inflammatory Response
Protein Modification By Small Protein Removal
Nucleus
Animal Organ Development
Regulation Of Cell Cycle G1/S Phase Transition
Cytoplasm
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Cellular Developmental Process
Cell Differentiation
Macromolecule Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Keratinocyte Differentiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Macromolecule Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Scaffold Protein Binding
MAPK Cascade
Cellular Response To Alkaloid
Regulation Of Protein Modification Process
Positive Regulation Of Programmed Cell Death
Post-translational Protein Modification
Protein Modification Process
Regulation Of Post-translational Protein Modification
Protein Tag Activity
Cullin-RING Ubiquitin Ligase Complex
Protein-containing Complex
Cellular Response To Starvation
Response To Nutrient Levels
Mitotic G1 DNA Damage Checkpoint Signaling
Rhythmic Synaptic Transmission
G1/S Transition Of Mitotic Cell Cycle
Mitotic G1/S Transition Checkpoint Signaling
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin Protein Ligase Binding
Proteasomal Protein Catabolic Process
Ubiquitin Binding
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Protein Modification Process
Protein Modification By Small Protein Conjugation
Cytosol
Positive Regulation Of Catabolic Process
Protein Modification By Small Protein Removal
Regulation Of Protein Metabolic Process
Nucleoplasm
Regulation Of Post-translational Protein Modification
Regulation Of Proteolysis
Protein Ubiquitination
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Protein Deubiquitination
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Proteolysis
Positive Regulation Of Protein Catabolic Process
Nucleus
Protein Polyubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Cullin-RING Ubiquitin Ligase Complex
DeNEDDylase Activity
Aggresome
ATP-dependent Protein Folding Chaperone
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Proteasomal Protein Catabolic Process
Protein Folding
Response To Stress
Protein Neddylation
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Stability
Positive Regulation Of Metabolic Process
Cellular Response To Stress
Cytoplasm
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Tagcloud (Intersection)
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