SLC2A1 and FAAH

Data Source: HiPPIP (Novel)

		SLC2A1	FAAH
Name		solute carrier family 2 member 1	fatty acid amide hydrolase
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Female Germ Cell Nucleus Photoreceptor Inner Segment Female Pronucleus Cytoplasm Cytosol Plasma Membrane Caveola Cell-cell Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Vesicle Sarcolemma Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Presynapse Glucose Transporter Complex	Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Endomembrane System Membrane Organelle Membrane Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding Fucose Transmembrane Transporter Activity Kinase Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Amidase Activity Protein Binding Phospholipid Binding Lipid Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Fatty Acid Amide Hydrolase Activity Identical Protein Binding Monoacylglycerol Lipase Activity
	Biological Process	Response To Hypoxia Central Nervous System Development Female Pregnancy Fucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance D-glucose Import Transmembrane Transport Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine D-glucose Transmembrane Transport	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Catabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Positive Regulation Of Vasoconstriction Monoacylglycerol Catabolic Process Regulation Of Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission
Pathways		Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis	Arachidonate metabolism
Drugs		Resveratrol Carboxymethylcellulose	Thiopental Methoxy arachidonyl fluorophosphonate 1-Dodecanol 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid Fostamatinib Medical Cannabis Nabiximols
Diseases		GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)	None
GWAS		Birth weight ( 31043758 ) Cardiac hypertrophy ( 21348951 ) Immature fraction of reticulocytes ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 27863252 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) White blood cell count ( 32888494 )	Body mass index ( 26426971 ) Lipid or lipoprotein levels ( 23696881 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Serum metabolite levels ( 33031748 )
Novel Interactors		9 novel interactors: ADNP BMP8B CDKN1C CHRNB4 FAAH GCN1 PTPRU SMAP2 ZRSR2	1 novel interactors: SLC2A1
Interacting Genes		18 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 TXNIP UBE2I USP2 VHL WWP1	1 interacting genes: NOTCH2NLA
Entrez ID		6513	2166
HPRD ID		00683	04244
Ensembl ID		ENSG00000117394	ENSG00000117480
Uniprot IDs		P11166 Q59GX2	O00519
PDB IDs		4PYP 5EQG 5EQH 5EQI 6THA	Not available
GO Terms Enriched among Interactors		Protein Folding In Endoplasmic Reticulum Perinuclear Region Of Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Protein Stability Small Protein Activating Enzyme Binding Protein Stabilization MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Catalytic Activity Protein Modification Process Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cell Communication Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-7 Response To Interleukin-7 Post-translational Protein Modification Protein Folding Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Transcription Factor Binding Positive Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transport Chemokine Receptor Activity Protein Modification By Small Protein Conjugation Endoplasmic Reticulum Quality Control Compartment Negative Regulation Of RNA Biosynthetic Process Regulation Of Lymphocyte Chemotaxis Unfolded Protein Binding Negative Regulation Of Transporter Activity Protein Metabolic Process Presynaptic Cytosol Peptide Binding Postsynaptic Cytosol Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic	Cerebral Cortex Development Fucose Transmembrane Transporter Activity Glucose Transporter Complex Fucose Transmembrane Transport Response To Thyroglobulin Triiodothyronine D-glucose Import Across Plasma Membrane Long-chain Fatty Acid Import Across Plasma Membrane Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity L-ascorbic Acid Metabolic Process Dehydroascorbic Acid Transport Female Pronucleus Long-chain Fatty Acid Import Into Cell Lipid Import Into Cell Female Germ Cell Nucleus Long-chain Fatty Acid Transmembrane Transporter Activity Cellular Hyperosmotic Response D-glucose Import Xenobiotic Transmembrane Transporter Activity Notch Binding Hyperosmotic Response D-glucose Transmembrane Transport Hexose Transmembrane Transport Cellular Response To Glucose Starvation Cellular Response To Osmotic Stress Carbohydrate Transport Vitamin Transport Xenobiotic Transport Photoreceptor Cell Maintenance Carbohydrate Transmembrane Transport Long-chain Fatty Acid Transport Intercalated Disc Positive Regulation Of Notch Signaling Pathway Cortical Actin Cytoskeleton Photoreceptor Inner Segment Response To Osmotic Stress Cellular Response To Mechanical Stimulus Caveola Transport Across Blood-brain Barrier Female Pregnancy Fatty Acid Transport Regulation Of Notch Signaling Pathway Kinase Binding Melanosome Sarcolemma Notch Signaling Pathway Blood Microparticle Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Monocarboxylic Acid Transport