COPS6 and LPL

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	LPL
Gene Name		COP9 signalosome subunit 6	lipoprotein lipase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix Anchored Component Of Membrane Very-low-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Receptor Binding Protein Binding Heparin Binding Triglyceride Binding Apolipoprotein Binding
	Biological Process	Cullin Deneddylation Viral Process	Retinoid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Phototransduction, Visible Light Response To Cold Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Triglyceride Biosynthetic Process Triglyceride Catabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Response To Drug Small Molecule Metabolic Process Triglyceride Homeostasis
Pathways			Lipoprotein metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs			Tyloxapol
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 23726366 20031538 21909109 18193043 18193044 20864672 19060906 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Triglycerides ( 23726366 21909109 18193043 18193044 18193046 20864672 19060906 19060911 22171074 20139978 17463246 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24	16 interactors: APOC2 APP ASCC2 CALR CCND1 CETP COPS6 EMD KIAA1377 LRP1 LRP2 LUC7L2 PTPN4 RPL18A UBE2Z VLDLR
Entrez ID		10980	4023
HPRD ID		16735	01999
Ensembl ID		ENSG00000168090	ENSG00000175445
Uniprot IDs		Q7L5N1	P06858
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death	Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Response To Light Stimulus Regulation Of Cholesterol Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Endocytosis Response To Radiation Regulation Of Plasma Lipoprotein Particle Levels Very-low-density Lipoprotein Particle Remodeling Phototransduction, Visible Light Retinoid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Reverse Cholesterol Transport Isoprenoid Metabolic Process Regulation Of Cholesterol Efflux Lipid Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Plasma Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Vesicle-mediated Transport Triglyceride Homeostasis Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Positive Regulation Of Cell Cycle Cholesterol Transport Sterol Transport Lipid Transport Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Lipid Localization Cholesterol Homeostasis Sterol Homeostasis Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally
Tagcloud (Intersection) ?