COPS6 and TDGF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	TDGF1
Gene Name		COP9 signalosome subunit 6	teratocarcinoma-derived growth factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cullin Deneddylation Viral Process	Activation Of MAPK Activity Vasculogenesis In Utero Embryonic Development Morphogenesis Of A Branching Structure Positive Regulation Of Cell-matrix Adhesion Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Gastrulation Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Somatic Stem Cell Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways			Transcriptional regulation of pluripotent stem cells Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24	10 interactors: ACVR1B ACVR1C ANG AP2S1 BAG6 COPS6 FARSA FBLN1 GDF9 LRIF1
Entrez ID		10980	6997
HPRD ID		16735	01757
Ensembl ID		ENSG00000168090	ENSG00000241186
Uniprot IDs		Q7L5N1	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death	Nodal Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Reproductive Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Oocyte Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Oogenesis Negative Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Trophoblast Cell Migration Oocyte Growth Female Gamete Generation Single Organism Reproductive Process Development Of Primary Female Sexual Characteristics Regulation Of Chorionic Trophoblast Cell Proliferation Negative Regulation Of Trophoblast Cell Migration Viral Process Positive Regulation Of Peptidase Activity Diacylglycerol Biosynthetic Process Phenylalanyl-tRNA Aminoacylation Activation Of Phospholipase A2 Activity Regulation Of Progesterone Secretion Negative Regulation Of Cell Growth Regulation Of Secretion Positive Regulation Of Phospholipase A2 Activity Gamete Generation Developmental Process Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Protein Insertion Into ER Membrane Cullin Deneddylation Sexual Reproduction Multicellular Organismal Reproductive Process Development Of Primary Sexual Characteristics Multicellular Organism Reproduction Negative Regulation Of Growth Positive Regulation Of Phosphorylation Protein Deneddylation Germ Cell Development
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Intersection) ?