COPS6 and MYCBP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	MYCBP
Description		COP9 signalosome subunit 6	MYC binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation	Regulation Of DNA-templated Transcription Spermatogenesis Positive Regulation Of DNA-templated Transcription
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Beard thickness ( 26926045) Menopause (age at onset) ( 26414677)
Interacting Genes		95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	17 interacting genes: AKAP1 ARHGEF40 CFAP91 CFL1 COPS6 CPNE1 CPNE2 CPNE4 DISP3 ERBB3 GDF9 MYC MYCBPAP PTN SSRP1 UBC UBE3A
Entrez ID		10980	26292
HPRD ID		16735	08406
Ensembl ID		ENSG00000168090	ENSG00000214114
Uniprot IDs		Q7L5N1	Q99417
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	2YY0
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Calcium-dependent Phospholipid Binding Cellular Response To Calcium Ion Cofilin-actin Rod Regulation Of Developmental Process Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Protein-containing Complex Disassembly Positive Regulation Of Protein Localization To Cell Leading Edge Regulation Of Epithelial Cell Proliferation Developmental Growth Protein-DNA Complex Disassembly Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Regulation Of Neuron Projection Regeneration Neuron Projection Regeneration Regulation Of Axon Regeneration Chondroitin Sulfate Proteoglycan Binding Sperm Entry Positive Regulation Of Golgi Lumen Acidification Cellular Response To Metal Ion Response To Calcium Ion Regulation Of Neuron Projection Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Synaptic Plasticity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Neuron Projection Development Negative Regulation Of Postsynaptic Density Organization Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Female Gamete Generation Regulation Of Progesterone Secretion Myc-Max Complex Regulation Of Acinar Cell Proliferation Dendrite Regeneration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Radial Spoke Stalk Developmental Process Involved In Reproduction
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