S100A10 and COPS6

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		S100A10	COPS6
Name		S100 calcium binding protein A10	COP9 signalosome subunit 6
Structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Membrane Raft Extracellular Exosome RNA Polymerase II Transcription Regulator Complex Plasma Membrane Protein Complex AnxA2-p11 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Transmembrane Transporter Binding Calcium-dependent Protein Binding	Protein Binding Peptidase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Membrane Raft Assembly Vesicle Budding From Membrane Positive Regulation Of Plasminogen Activation MRNA Transcription By RNA Polymerase II Positive Regulation Of GTPase Activity Positive Regulation Of Exocytosis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Plasma Membrane Repair	Protein Deneddylation Protein Neddylation Regulation Of Protein Neddylation
Pathways		Dissolution of Fibrin Clot	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs		Phenethyl Isothiocyanate	None
GWAS		Asthma ( 31619474 ) Diverticular disease ( 30177863 ) Serum metabolite levels ( 33031748 ) Urinary metabolite levels in chronic kidney disease ( 29545352 ) Urinary metabolite ratios in chronic kidney disease ( 29545352 )	Brain morphology (MOSTest) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		23 interacting genes: ANXA2 ANXA7 BAD CBR3 CDK16 COPS6 CTSB DSCAM ERBB3 FSHR KCNK3 MLKL NANOS2 PLA2G4C PLG S100A3 S100Z SETDB1 SUMO2 TRPV5 TRPV6 USP2 ZGPAT	95 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CRIPTO CUL1 CUL5 DIS3L2 DLEU1 DSP EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHANK3 SHC3 SLC2A1 SMN1 SNRPG STAMBPL1 STK40 STX5 SULT1E1 TK1 TP53 TP63 TRDMT1 TRIB3 UBC USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		6281	10980
HPRD ID		00232	16735
Ensembl ID		ENSG00000197747	ENSG00000168090
Uniprot IDs		P60903	Q7L5N1
PDB IDs		1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH	4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F
GO Terms Enriched among Interactors		Calcium-dependent Protein Binding Calcium-dependent Phospholipid Binding Plasma Membrane S100 Protein Binding	Protein Neddylation Protein Deneddylation Regulation Of Protein Neddylation Nucleoplasm Heart Development COP9 Signalosome Developmental Process Cytosol Cellular Response To Staurosporine Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction By P53 Class Mediator Cellular Response To Nutrient Levels Protein Binding Positive Regulation Of Neuron Apoptotic Process Protease Binding Pyroptotic Inflammatory Response Protein Modification By Small Protein Removal Nucleus Animal Organ Development Regulation Of Cell Cycle G1/S Phase Transition Cytoplasm Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Developmental Process Cell Differentiation Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Keratinocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Scaffold Protein Binding MAPK Cascade Cellular Response To Alkaloid Regulation Of Protein Modification Process Positive Regulation Of Programmed Cell Death Post-translational Protein Modification Protein Modification Process Regulation Of Post-translational Protein Modification Protein Tag Activity Cullin-RING Ubiquitin Ligase Complex Protein-containing Complex Cellular Response To Starvation Response To Nutrient Levels Mitotic G1 DNA Damage Checkpoint Signaling Rhythmic Synaptic Transmission G1/S Transition Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint Signaling