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UBE2E3 and NFKBIA
Number of citations of the paper that reports this interaction (PubMedID
10582246
)
95
Data Source:
HPRD
(two hybrid, in vitro)
UBE2E3
NFKBIA
Description
ubiquitin conjugating enzyme E2 E3
NFKB inhibitor alpha
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
I-kappaB/NF-kappaB Complex
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Protein Binding
Nuclear Localization Sequence Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
NF-kappaB Binding
Protein Sequestering Activity
Transcription Regulator Inhibitor Activity
Biological Process
Protein Monoubiquitination
Negative Regulation Of Gene Expression
Protein Ubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Negative Regulation Of Transcription By RNA Polymerase II
Immune System Process
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Inflammatory Response
Notch Signaling Pathway
Canonical NF-kappaB Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Cholesterol Transport
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Negative Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Cold
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
SARS-CoV-1 activates/modulates innate immune responses
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Acetylsalicylic acid
Bardoxolone methyl
Astaxanthin
Diseases
Hodgkin lymphoma
Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect
GWAS
Ankylosing spondylitis (
23749187
)
Basophil count (
32888494
)
Body mass index (
25673413
)
Celiac disease (
22057235
20190752
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Heel bone mineral density (
30598549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Lymphocyte count (
29403010
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Obesity (
21552555
)
QT interval (
29213071
)
Red blood cell count (
27863252
32888494
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Serum alkaline phosphatase levels (
33547301
)
Sweet taste preference (
32572145
)
White blood cell count (
27863252
)
Appendicular lean mass (
33097823
)
Asthma (
32296059
30929738
)
Asthma (childhood onset) (
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Creatine kinase levels (
29403010
)
Eczema (
31361310
)
Hip circumference adjusted for BMI (
25673412
)
Inflammatory skin disease (
25574825
)
Lymphocyte count (
32888494
27863252
)
PR interval (
32439900
)
Psoriasis (
20953190
25903422
25854761
25574825
23143594
20953189
)
Psoriasis vulgaris (
26626624
)
Pulse pressure (
30578418
27841878
)
Rheumatoid arthritis (
32723749
)
Systolic blood pressure (
28739976
27841878
30578418
)
White blood cell count (
32888494
)
Interacting Genes
95 interacting genes:
ACVR1
ARID3A
ARIH2
ARK2C
ARRDC3
ASXL2
ATXN1
BARD1
BRCA1
CADPS2
CBL
CHFR
CHUK
CNOT4
CUEDC1
CUL1
CUL3
CUL4A
DAZAP2
DTX3
DTX3L
DZIP3
HERC4
HMGB1
HTT
IPO11
ITCH
KLHL42
MARCHF5
MDM2
MID1
MID2
MKRN3
MUL1
NEDD4L
NFKBIA
PGPEP1
PICK1
PJA1
PRKN
RANGAP1
RBX1
RC3H2
RCBTB1
RFWD3
RING1
RMND5B
RNF11
RNF111
RNF114
RNF115
RNF126
RNF13
RNF130
RNF14
RNF150
RNF166
RNF167
RNF181
RNF185
RNF2
RNF31
RNF4
RNF43
RNF5
RNF8
SAE1
SIAH1
SPOP
STUB1
TGFBR1
TRIM2
TRIM27
TRIM32
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TTC3
UBA1
UBA6
UBC
UBOX5
UFM1
WBP2
WWP2
ZNF746
ZNRF1
ZNRF2
ZNRF4
92 interacting genes:
ABL1
ARRB1
ARRB2
ATF4
AURKA
BARD1
BTRC
CAPN1
CAPN2
CD7
CDC34
CHUK
COMMD1
COPS8
CSNK2A1
CUL1
DNAJA3
DYNLL1
EIF2AK2
ELP1
ENKD1
FBXW11
G3BP2
HDAC1
HDAC3
HNRNPA1
HOXA9
HOXB7
HSPB1
IKBKB
IKBKE
IKBKG
IKZF4
ITPK1
JAK2
LCK
LYL1
MAP3K1
MAP3K14
MAP3K2
MAP3K3
MAP3K7
MCM5
MCM7
MED19
NCOR2
NEDD9
NFKB1
NFKB2
NFKBIB
NKIRAS1
NKIRAS2
PIK3R1
PIR
POLR2C
POM121
PRKCA
PRKCI
PSMA2
PSMD3
PTPN1
PTPN13
REL
RELA
RNF115
RPS6KA1
RPS6KA3
RWDD3
SKP1
SLC25A4
SLC25A5
SRC
ST7
SUMO1
SUMO4
TBK1
TCL1A
TNF
TNFSF11
TP53
TUBA1B
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2I
UBE2L3
UBE2M
UBE2S
USP39
VCP
ZNF212
Entrez ID
10477
4792
HPRD ID
05000
01235
Ensembl ID
ENSG00000170035
ENSG00000100906
Uniprot IDs
Q969T4
P25963
PDB IDs
1IKN
1NFI
6TTU
6Y1J
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Activity
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Post-translational Protein Modification
Protein Polyubiquitination
Protein Modification Process
Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Transferase Activity
Proteolysis Involved In Protein Catabolic Process
Protein Metabolic Process
Macromolecule Catabolic Process
Zinc Ion Binding
Proteolysis
Protein Autoubiquitination
Macromolecule Metabolic Process
Catabolic Process
Protein K48-linked Ubiquitination
Metal Ion Binding
Cytoplasm
Protein K63-linked Ubiquitination
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Protein Monoubiquitination
Response To Stress
Regulation Of Signaling
Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Ubiquitin Ligase Complex
Positive Regulation Of Catabolic Process
Protein Destabilization
Protein K6-linked Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Autophagy
Defense Response To Symbiont
Positive Regulation Of Metabolic Process
Cellular Response To Stress
Defense Response To Other Organism
Regulation Of Canonical NF-kappaB Signal Transduction
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Protein Modification Process
Cytosol
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Canonical NF-kappaB Signal Transduction
Macromolecule Metabolic Process
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
ATP Binding
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Modification-dependent Protein Catabolic Process
Protein Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Negative Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
Negative Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Protein Modification By Small Protein Conjugation
Protein Kinase Activity
Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of DNA-templated Transcription
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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