UBE2E3 and RCBTB1

Number of citations of the paper that reports this interaction (PubMedID 19256485)
54

Data Source:
BioGRID (pull down)

		UBE2E3	RCBTB1
Description		ubiquitin conjugating enzyme E2 E3	RCC1 and BTB domain containing protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding
	Biological Process	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Chromatin Organization
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Breastfeeding duration ( 25475840) Granulocyte count ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Refractive error ( 32231278) Schizophrenia ( 33169155) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 33536424) White blood cell count ( 32888494)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF2 ZNRF4	4 interacting genes: APP CUL3 DSCAM UBE2E3
Entrez ID		10477	55213
HPRD ID		05000	09713
Ensembl ID		ENSG00000170035	ENSG00000136144
Uniprot IDs		Q969T4	B3KR20 Q8NDN9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Central Nervous System Development Regulation Of Response To Calcium Ion Cell Recognition Positive Regulation Of Chemotaxis Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Growth Cone Neuron Recognition Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Protein Catabolic Process At Postsynapse Protein K48-linked Ubiquitination Protein Monoubiquitination Trophectodermal Cellular Morphogenesis Liver Morphogenesis Positive Regulation Of Cellular Component Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Postsynapse Intermediate-density Lipoprotein Particle Negative Regulation Of Gene Expression Regulation Of Chemotaxis Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Cell Projection Organization Growth Factor Receptor Binding Main Axon Locomotory Behavior Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling POZ Domain Binding Polar Microtubule Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway
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