UBE2E3 and MID1

Number of citations of the paper that reports this interaction (PMID 21143188)
10

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		UBE2E3	MID1
Gene Name		ubiquitin-conjugating enzyme E2E 3	midline 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Spindle Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity	Microtubule Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Phosphoprotein Binding
	Biological Process	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Interferon-gamma-mediated Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Obesity ( 21552555)
Protein-Protein Interactions		75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4	30 interactors: BYSL DYRK4 EHHADH FKBP1A GMCL1 HTT IGBP1 MEOX1 MID1IP1 MID2 OTUB2 PKN1 PPP2CA PPP2CB PPP2R4 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1
Entrez ID		10477	4281
HPRD ID		05000	02047
Ensembl ID		ENSG00000170035	ENSG00000101871
Uniprot IDs		Q969T4	O15344
PDB IDs			2DQ5 2FFW 2JUN
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Cellular Protein Modification Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Cellular Metabolic Process Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Proteasomal Protein Catabolic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Innate Immune Response Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Cellular Response To Stress Proteolysis Positive Regulation Of Protein Modification Process Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Innate Immune Response Regulation Of Dephosphorylation Protein Monoubiquitination Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation ISG15-protein Conjugation Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression Cellular Response To Organic Substance Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity
Tagcloud ?		conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved	adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation homeostasis kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p outer pba phenyl reinforce remarkably
Tagcloud (Difference) ?		conjugating cytoprotective degraded extracting govern imp import importin keap1 locales localizes mitochondria nrf2 p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved	adds alleviated amount biosynthesis butyrate depleted droplet dtt encodes ergosterol glycoproteins glycosylation kloch1 kluyveromyces lactis ld lds lipid mannosyltrasferase misfolding mobilization och1 och1p pba phenyl reinforce remarkably
Tagcloud (Intersection) ?		homeostasis outer