UBE2E3 and TRIM50

Number of citations of the paper that reports this interaction (PMID 21143188)
10

Data Source:
BioGRID (two hybrid, two hybrid)

		UBE2E3	TRIM50
Gene Name		ubiquitin-conjugating enzyme E2E 3	tripartite motif containing 50
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity	Zinc Ion Binding Ligase Activity
	Biological Process	Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Obesity ( 21552555)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		75 interactors: ACVR1 ARID3A ARIH2 ATXN1 BARD1 BRCA1 CADPS2 CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCH5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA RBX1 RCBTB1 RCBTB2 RFWD3 RING1 RMND5B RNF10 RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBC UBOX5 UFM1 WWP2 ZNRF1 ZNRF4	9 interactors: HDAC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N
Entrez ID		10477	135892
HPRD ID		05000	15566
Ensembl ID		ENSG00000170035	ENSG00000146755
Uniprot IDs		Q969T4	B7ZLG2 Q2M204 Q86XT4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Metabolic Process Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Histone Ubiquitination Histone H2A Ubiquitination Regulation Of Protein Catabolic Process Cell Cycle Histone Monoubiquitination Response To Stress Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Type I Interferon Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cellular Response To Stress Protein K6-linked Ubiquitination Cell Cycle Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Mitotic Cell Cycle	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process ISG15-protein Conjugation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Proteolysis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Catabolic Process Positive Regulation Of Protein Ubiquitination Immune Response-regulating Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Positive Regulation Of Immune Response Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Checkpoint
Tagcloud ?		conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved	acetylation acetyltransferases aggresome balance clearance critical deacetylase degradation dependent e3 formation hdac6 identified interaction ligase lys microtubule p300 pcaf polyubiquitinated promotes regulates report residue showed target tubulin ubiquitin ubiquitination
Tagcloud (Difference) ?		conjugating cytoprotective degraded extracting govern homeostasis imp import importin keap1 locales localizes mitochondria nrf2 outer p45 partitioning perinuclear prematurely relocalizes repressive restore restrict restricting subcellular tightly transcriptionally unresolved	acetylation acetyltransferases aggresome balance clearance critical deacetylase degradation dependent e3 formation hdac6 identified interaction ligase lys microtubule p300 pcaf polyubiquitinated promotes regulates report residue showed target tubulin ubiquitin ubiquitination
Tagcloud (Intersection) ?