UBE2E3 and RFWD3

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UBE2E3	RFWD3
Description		ubiquitin conjugating enzyme E2 E3	ring finger and WD repeat domain 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm PML Body Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Interstrand Cross-link Repair Regulation Of DNA Damage Checkpoint
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Adult body size ( 32376654) Experiencing mood swings ( 29500382) Leukocyte telomere length ( 32109421) Multiple myeloma ( 27363682) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF2 ZNRF4	17 interacting genes: APP CFTR ORC1 ORC2 PCNA RAD51 RPA1 RPA3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		10477	55159
HPRD ID		05000	07678
Ensembl ID		ENSG00000170035	ENSG00000168411
Uniprot IDs		Q969T4	Q6PCD5
PDB IDs			6CVZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Monoubiquitination Protein Modification By Small Protein Conjugation ATP Binding DNA Metabolic Process Macromolecule Metabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Nucleus Protein K11-linked Ubiquitination Nucleotide Binding Proteolysis Involved In Protein Catabolic Process DNA Replication DNA Repair Nucleoplasm Ubiquitin-dependent Protein Catabolic Process Chromosome, Telomeric Region Telomere Maintenance Macromolecule Catabolic Process Mismatch Repair DNA Damage Response Telomere Organization Proteolysis Protein Modification Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Origin Recognition Complex Male Germ Cell Nucleus Nuclear Origin Of Replication Recognition Complex TORC1 Signaling Damaged DNA Binding Negative Regulation Of TORC1 Signaling Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Stress Protein-containing Complex Double-strand Break Repair DNA Replication Factor A Complex DNA Recombination TOR Signaling Chromatin Binding Lateral Element Negative Regulation Of TOR Signaling DNA Replication Origin Binding Transferase Activity Site Of Double-strand Break
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