UBE2E3 and RC3H2

Number of citations of the paper that reports this interaction (PubMedID 26489670)
51

Data Source:
BioGRID (pull down)

		UBE2E3	RC3H2
Description		ubiquitin conjugating enzyme E2 E3	ring finger and CCCH-type domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	P-body Cytoplasm Cell Surface Cytoplasmic Stress Granule Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding RNA Binding Double-stranded RNA Binding MRNA Binding Zinc Ion Binding Transferase Activity RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay B Cell Homeostasis Ubiquitin-dependent Protein Catabolic Process Post-embryonic Development Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Multicellular Organism Growth T Cell Proliferation T Cell Homeostasis Lung Alveolus Development Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Limb Development T Follicular Helper Cell Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF2 ZNRF4	13 interacting genes: TRIM8 UBC UBE2B UBE2D2 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2N UBE2Q2 UBE2V1 UBE2V2
Entrez ID		10477	54542
HPRD ID		05000	14726
Ensembl ID		ENSG00000170035	ENSG00000056586
Uniprot IDs		Q969T4	A6NHN2 Q9HBD1
PDB IDs			4Z30 4Z31 4ZLC 4ZLD
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Protein Ubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Postreplication Repair Positive Regulation Of Protein K63-linked Ubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process ATP Binding Regulation Of Protein K63-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleotide Binding Error-free Postreplication DNA Repair Regulation Of Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Monoubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleus Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process DNA Double-strand Break Processing Cellular Response To Interferon-beta DNA Damage Response Catabolic Process Response To Interferon-beta Regulation Of DNA Metabolic Process Regulation Of Protein Ubiquitination DNA Repair Cellular Response To Stress Positive Regulation Of Signal Transduction Regulation Of DNA Repair SUMO Conjugating Enzyme Activity
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