UBE2E3 and RNF13

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2E3	RNF13
Description		ubiquitin conjugating enzyme E2 E3	ring finger protein 13
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nuclear Inner Membrane Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Late Endosome Membrane
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding JUN Kinase Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of JNK Cascade Organelle Localization Protein Autoubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte count ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sweet taste preference ( 32572145) White blood cell count ( 27863252)	Fish- and plant-related diet ( 32066663) Myocardial infarction ( 26708285)
Interacting Genes		95 interacting genes: ACVR1 ARID3A ARIH2 ARK2C ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUEDC1 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 HERC4 HMGB1 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBA6 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF2 ZNRF4	10 interacting genes: LGALS9 SNAPIN TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N
Entrez ID		10477	11342
HPRD ID		05000	11503
Ensembl ID		ENSG00000170035	ENSG00000082996
Uniprot IDs		Q969T4	O43567
PDB IDs			5ZBU 5ZC4
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Protein Autoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K48-linked Ubiquitination Metal Ion Binding Cytoplasm Protein K63-linked Ubiquitination Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein Monoubiquitination Response To Stress Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Positive Regulation Of Catabolic Process Protein Destabilization Protein K6-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Autophagy Defense Response To Symbiont Positive Regulation Of Metabolic Process Cellular Response To Stress Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Ubiquitination Protein Monoubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination ATP Binding Protein K63-linked Ubiquitination Protein Modification Process Macromolecule Catabolic Process Nucleotide Binding Transferase Activity Proteolysis Positive Regulation Of Protein Polyubiquitination Protein Metabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Activated T Cell Autonomous Cell Death Positive Regulation Of Late Endosome To Lysosome Transport TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Disaccharide Binding Ubiquitin Protein Ligase Activity TOR Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Natural Killer Cell Tolerance Induction Regulation Of TORC1 Signaling UBC13-MMS2 Complex Regulation Of RNA Metabolic Process Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of DNA-binding Transcription Factor Activity
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