AFAP1 and ACTA1

Number of citations of the paper that reports this interaction (PMID 10666339)
10

Data Source:
HPRD (in vitro, in vivo)

		AFAP1	ACTA1
Gene Name		actin filament associated protein 1	actin, alpha 1, skeletal muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Focal Adhesion Actin Cytoskeleton	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding
	Biological Process	Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Cell Growth Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC	107 interactors: ABL1 ABRA ACTR10 ACTR1B ADSS AFAP1 AIF1 AJUBA AMOT CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		60312	58
HPRD ID		09747	00030
Ensembl ID		ENSG00000196526	ENSG00000143632
Uniprot IDs		Q6ZRV0 Q8N556	P68133 Q5T8M7
PDB IDs			1T44
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Blood Coagulation Hemostasis Regulation Of Cellular Response To Insulin Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Activation Of Phospholipase C Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phospholipase C Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Phosphorylation Peptidyl-serine Phosphorylation Histone H3-T6 Phosphorylation Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Peptidyl-amino Acid Modification Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Phosphorylation Cell Death Intracellular Signal Transduction Death Cellular Response To Organic Substance Peptidyl-threonine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Actin Filament-based Movement Muscle Contraction Muscle System Process Cell Projection Organization Organelle Organization Negative Regulation Of Protein Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cytoskeleton Organization Cellular Component Assembly Developmental Process Anatomical Structure Morphogenesis Anatomical Structure Development Negative Regulation Of Protein Complex Assembly System Development Actin-mediated Cell Contraction Response To Wounding Locomotion Cell Development Response To External Stimulus Cell Differentiation Wound Healing Multicellular Organismal Development Cell Morphogenesis Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Tissue Development Cell Projection Morphogenesis Chemotaxis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Neuron Development Actin Polymerization Or Depolymerization Blood Coagulation Hemostasis Cell Junction Assembly
Tagcloud ?			annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Difference) ?			annotation assembled biomedical contigs cox1 discover eef1a1 eef1g ends est ests expand gluconeogenesis libraries livestock loin normalized ontology pfam pig pituitary porcine singletons sla slc25a6 susflecks tags transducin wd40
Tagcloud (Intersection) ?