AFAP1 and ACTC1

Number of citations of the paper that reports this interaction (PMID 12134071)
8

Data Source:
HPRD (in vivo)

		AFAP1	ACTC1
Gene Name		actin filament associated protein 1	actin, alpha, cardiac muscle 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Focal Adhesion Actin Cytoskeleton	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Membrane Sarcomere I Band Actomyosin, Actin Portion Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization	Apoptotic Process Metabolic Process Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177) Refractive error ( 20835239)
Protein-Protein Interactions		9 interactors: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC	35 interactors: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FSCN1 GAPDH GC HSPB1 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 WAS WIPF1
Entrez ID		60312	70
HPRD ID		09747	00015
Ensembl ID		ENSG00000196526	ENSG00000159251
Uniprot IDs		Q6ZRV0 Q8N556	B3KPP5 P68032
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Blood Coagulation Hemostasis Regulation Of Cellular Response To Insulin Stimulus Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Activation Of Phospholipase C Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phospholipase C Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Protein Phosphorylation Peptidyl-serine Phosphorylation Histone H3-T6 Phosphorylation Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Peptidyl-amino Acid Modification Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Phosphorylation Cell Death Intracellular Signal Transduction Death Cellular Response To Organic Substance Peptidyl-threonine Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Regulation Of MAPK Cascade Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Regulation Of Immune System Process	Actin Filament-based Process Actin Cytoskeleton Organization Cytoskeleton Organization Actin Filament Organization Organelle Organization Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Actin Filament-based Movement Phagocytosis Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Cellular Localization Actin Filament Bundle Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Platelet Activation Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Sodium Ion Transmembrane Transport Wound Healing Positive Regulation Of Organelle Organization Vesicle-mediated Transport Endocytosis Nucleus Localization Negative Regulation Of Protein Complex Assembly Maintenance Of Protein Location In Cell Cell Activation Positive Regulation Of Wound Healing Maintenance Of Protein Location Immune Response-regulating Signaling Pathway Maintenance Of Location In Cell Response To Wounding Cell Projection Assembly
Tagcloud ?			accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Difference) ?			accompany ach3 ach4 cardiac cardiomyocytes cardiomyogenic cd29 commitment cscs elusive fate hdac hdac1 hdac2 hypothesize indicative loci mark modifications mscs myh6 myl2 noticed possess sca stronger tnni3 tnnt2 trichostatin
Tagcloud (Intersection) ?