AFAP1

Description		actin filament associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton
	Molecular Function	Actin Binding
	Biological Process	Regulation Of Signal Transduction
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 25861811 33627673 29452408 25173105 27623284 29891935) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Intraocular pressure ( 29617998 29235454 31959993 30054594 29785010) Lung function (FEV1/FVC) ( 30804560 30061609) Medication use (antiglaucoma preparations and miotics) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 27618447) Response to antidepressants (symptom improvement) ( 29160301) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC
Entrez ID		60312
HPRD ID		09747
Ensembl ID		ENSG00000196526
Uniprot IDs		Q6ZRV0 Q8N556
PDB IDs
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity ATP Binding Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Protein Kinase Activity Nucleotide Binding Kinase Activity Protein Phosphorylation Protein Serine Kinase Activity Phosphorylation Protein Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Hormone Response To Peptide Hormone Fc Receptor Mediated Stimulatory Signaling Pathway Histone H3T6 Kinase Activity Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Negative Regulation Of Programmed Cell Death Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Cell-cell Junction Mesenchyme Migration Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transferase Activity Skeletal Muscle Thin Filament Assembly Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Signaling Receptor Activator Activity Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Immune Response Actin Filament Extracellular Exosome Positive Regulation Of Insulin Secretion Negative Regulation Of Glial Cell Apoptotic Process Perinuclear Region Of Cytoplasm Mitotic Nuclear Membrane Disassembly Positive Regulation Of Establishment Of Protein Localization Phosphate-containing Compound Metabolic Process
Tagcloud ?