RB1 and KEAP1

Number of citations of the paper that reports this interaction (PubMedID 36163178)
24

Data Source:
BioGRID (pull down)

		RB1	KEAP1
Description		RB transcriptional corepressor 1	kelch like ECH associated protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Spindle Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex SWI/SNF Complex PML Body Rb-E2F Complex Chromatin Lock Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Protein-containing Complex Centriolar Satellite
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Tissue Homeostasis Chondrocyte Differentiation Aortic Valve Morphogenesis Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Protein Kinase Activity Apoptotic Process Smoothened Signaling Pathway Ras Protein Signal Transduction Spermatogenesis Regulation Of Mitotic Cell Cycle Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Glial Cell Proliferation Cell Differentiation Neuron Differentiation Negative Regulation Of Cell Growth Sister Chromatid Biorientation Neuron Projection Development Heterochromatin Formation Developmental Process Cellular Response To Insulin Stimulus Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Striated Muscle Cell Differentiation Chromosome Organization Cell Division Neuron Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Glial Cell Proliferation Protein Localization To Chromosome, Centromeric Region Cellular Response To Xenobiotic Stimulus Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Myofibroblast Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Cell Differentiation Protein K48-linked Ubiquitination Cellular Response To Interleukin-4 Negative Regulation Of Response To Oxidative Stress
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome Nuclear events stimulated by ALK signaling in cancer Positive Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Ub-specific processing proteases Neddylation Potential therapeutics for SARS KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Dimethyl fumarate
Diseases		Chronic myeloid leukemia (CML) Breast cancer Osteosarcoma Hepatocellular carcinoma Small cell lung cancer Esophageal cancer Glioma Bladder cancer
GWAS		Birth weight ( 27680694 31043758) Chronic kidney disease ( 26420894) Diastolic blood pressure ( 34074324) Lymphocyte count ( 32888494) Offspring birth weight ( 31043758) Post bronchodilator FEV1/FVC ratio ( 26634245)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		194 interacting genes: AATF ABL1 AHR ANKS1A AR ARID3B ATF2 BAAT BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX4 CCDC180 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CHN2 CLNK CORO2A CREG1 CTBP1 CTSV CUX1 DGKZ DNMT1 DVL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FANCC FBP1 FBP2 FOS FOXM1 FRK FZR1 GALNT12 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B KEAP1 KMT5C L3MBTL1 LEF1 LIN54 LIN9 LMNA MAPK1 MAPK14 MAPK3 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCF1 NCOA6 NDC80 NEFM ORC1 PA2G4 PAX2 PAX5 PAX6 PELP1 PHB1 PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PPP1R26 PPP1R9B PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RABGAP1L RACK1 RAF1 RASA1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF123 RNF40 RUNX2 SERPINB2 SHC1 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 STX17 SUV39H1 TAF1 TASOR TBP TFAP2A TGM2 THOC1 TMPO TOP2A TRAP1 TRIM27 TRIM28 TRIP11 TRMO UBE2I UBTF USP4 USP7 VDR XPA ZBTB16	93 interacting genes: AK4 AMER1 ANKS1A ASTN1 ATF5 ATG5 BAD BPTF BTRC C2orf68 C6orf132 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DDRGK1 EAF1 EGFR ERICH5 ETF1 FAM117B FBXL17 FXR1 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL24 KPNA6 LAMC1 LAMTOR5 LINC00239 LSM3 MAD2L1 MAPKBP1 MCC MCMBP MLST8 MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PAK1 PAQR4 PDCD6IP PLEC PRKAG1 PTMA PTTG1 RAF1 RB1 RBX1 RECK RELA RNF26 SGCE SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRERF1 TRIM15 TRIM59 UBC UBE2D1 USP15 WDR83 WHRN ZNF121 ZSCAN32
Entrez ID		5925	9817
HPRD ID		01574	12079
Ensembl ID		ENSG00000139687	ENSG00000079999
Uniprot IDs		A0A2R8YFL6 A0A3B3IS71 P06400	Q14145
PDB IDs		1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL 9DGK 9DHC 9DHF 9DHU	1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A 7EXI 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2F 7K2G 7K2H 7K2I 7K2J 7K2K 7K2L 7K2M 7K2N 7K2O 7K2P 7K2Q 7K2R 7K2S 7Q5H 7Q6Q 7Q6S 7Q8R 7Q96 7X4W 7X4X 7XM2 7XM3 7XM4 7XM5 7XOT 8EHV 8EJR 8EJS 8IVG 8IVR 8IXS 8PKS 8PKU 8PKV 8PKW 8PKX 8WFG 8X34 8XGK 8XGV 9DU7 9ETX 9ETY
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Damage Response Chromatin Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death DNA-templated Transcription Regulation Of Apoptotic Process Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Mitotic Cell Cycle RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction DNA Binding Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Metabolic Process Response To Stress	Identical Protein Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Negative Regulation Of Catabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Catabolic Process Response To Oxygen Levels Positive Regulation Of Biosynthetic Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Autophagy Import Into Nucleus Negative Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Programmed Cell Death Regulation Of Type I Interferon Production
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