RB1 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 9003781)
55

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, enzymatic study)
HPRD (in vitro, in vivo)

		RB1	CCND2
Description		RB transcriptional corepressor 1	cyclin D2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Spindle Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex SWI/SNF Complex PML Body Rb-E2F Complex Chromatin Lock Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Membrane Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Tissue Homeostasis Chondrocyte Differentiation Aortic Valve Morphogenesis Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Protein Kinase Activity Apoptotic Process Smoothened Signaling Pathway Ras Protein Signal Transduction Spermatogenesis Regulation Of Mitotic Cell Cycle Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Glial Cell Proliferation Cell Differentiation Neuron Differentiation Negative Regulation Of Cell Growth Sister Chromatid Biorientation Neuron Projection Development Heterochromatin Formation Developmental Process Cellular Response To Insulin Stimulus Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Striated Muscle Cell Differentiation Chromosome Organization Cell Division Neuron Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Glial Cell Proliferation Protein Localization To Chromosome, Centromeric Region Cellular Response To Xenobiotic Stimulus Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Myofibroblast Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Cell Division Regulation Of Cell Cycle Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome Nuclear events stimulated by ALK signaling in cancer Positive Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs
Diseases		Chronic myeloid leukemia (CML) Breast cancer Osteosarcoma Hepatocellular carcinoma Small cell lung cancer Esophageal cancer Glioma Bladder cancer	Testicular cancer
GWAS		Birth weight ( 27680694 31043758) Chronic kidney disease ( 26420894) Diastolic blood pressure ( 34074324) Lymphocyte count ( 32888494) Offspring birth weight ( 31043758) Post bronchodilator FEV1/FVC ratio ( 26634245)	Alanine aminotransferase levels ( 34315874) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 24836286 31826910 26151821 30529582 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28270201 28552196) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 31928498 32154731 32203549) Type 2 diabetes ( 30297969 31118516 30054458 29358691 28869590 32499647 22885922) Waist circumference ( 31928498)
Interacting Genes		194 interacting genes: AATF ABL1 AHR ANKS1A AR ARID3B ATF2 BAAT BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX4 CCDC180 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CHN2 CLNK CORO2A CREG1 CTBP1 CTSV CUX1 DGKZ DNMT1 DVL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FANCC FBP1 FBP2 FOS FOXM1 FRK FZR1 GALNT12 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B KEAP1 KMT5C L3MBTL1 LEF1 LIN54 LIN9 LMNA MAPK1 MAPK14 MAPK3 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCF1 NCOA6 NDC80 NEFM ORC1 PA2G4 PAX2 PAX5 PAX6 PELP1 PHB1 PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PPP1R26 PPP1R9B PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RABGAP1L RACK1 RAF1 RASA1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF123 RNF40 RUNX2 SERPINB2 SHC1 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 STX17 SUV39H1 TAF1 TASOR TBP TFAP2A TGM2 THOC1 TMPO TOP2A TRAP1 TRIM27 TRIM28 TRIP11 TRMO UBE2I UBTF USP4 USP7 VDR XPA ZBTB16	64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		5925	894
HPRD ID		01574	00451
Ensembl ID		ENSG00000139687	ENSG00000118971
Uniprot IDs		A0A2R8YFL6 A0A3B3IS71 P06400	P30279
PDB IDs		1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL 9DGK 9DHC 9DHF 9DHU	6EI2
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Damage Response Chromatin Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death DNA-templated Transcription Regulation Of Apoptotic Process Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Mitotic Cell Cycle RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction DNA Binding Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Metabolic Process Response To Stress	Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Communication Regulation Of Signaling Kinase Activity Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Cell Population Proliferation Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase Binding Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Developmental Process Positive Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Growth Regulation Of Apoptotic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Cellular Senescence Regulation Of Catalytic Activity Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Regulation Of Developmental Process Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cell Differentiation
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