KEAP1 and ETF1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		KEAP1	ETF1
Gene Name		kelch-like ECH-associated protein 1	eukaryotic translation termination factor 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Transcription Factor Binding	RNA Binding Translation Release Factor Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Poly(A) RNA Binding
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Gene Expression Cellular Protein Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Translation Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	5 interactors: GSPT1 GSPT2 KEAP1 LIG4 PPP2CA
Entrez ID		9817	2107
HPRD ID		12079	02616
Ensembl ID		ENSG00000079999	ENSG00000120705
Uniprot IDs		Q14145	B7Z7P8 P62495 Q96CG1
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK	1DT9 2HST 2KTU 2KTV 2LGT 2LLX 3E1Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Cell Cycle Aromatic Compound Catabolic Process MRNA Metabolic Process Catabolic Process DNA Ligation Involved In DNA Recombination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Translational Termination Cellular Nitrogen Compound Metabolic Process Cellular Protein Complex Disassembly Nitrogen Compound Metabolic Process Protein Complex Disassembly Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Lagging Strand Elongation Pro-B Cell Differentiation Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Mitotic Nuclear Envelope Reassembly Establishment Of Viral Latency Gene Expression T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Protein Heterotrimerization Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Nuclear Envelope Reassembly Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of Cell Differentiation DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Negative Regulation Of Epithelial To Mesenchymal Transition In Utero Embryonic Development Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of JAK-STAT Cascade Cellular Protein Metabolic Process Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Protein Autophosphorylation
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	adequate axillary classification classifier classifiers differentially enough eny2 fbx033 flj339115 flj33915 heterogeneity indicative infiltrated malignancy multiplex nodes osbpl parts predicting prognostic rps7 sets solely subdivides subgroup subtype usp38 validate
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	adequate axillary classification classifier classifiers differentially enough eny2 fbx033 flj339115 flj33915 heterogeneity indicative infiltrated malignancy multiplex nodes osbpl parts predicting prognostic rps7 sets solely subdivides subgroup subtype usp38 validate
Tagcloud (Intersection) ?