Wiki-Pi
About
Search
People
Updates
Search
RB1 and HSPA8
Number of citations of the paper that reports this interaction (PubMedID
7673249
)
0
Data Source:
BioGRID
(pull down, affinity chromatography technology)
HPRD
(in vivo, in vitro)
RB1
HSPA8
Description
RB transcriptional corepressor 1
heat shock protein family A (Hsp70) member 8
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Spindle
Cytosol
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Chromatin Lock Complex
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Secretory Granule Lumen
Melanosome
Lysosomal Lumen
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Protein Folding Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Nucleotide Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Receptor Ligand Activity
Unfolded Protein Binding
Protein-folding Chaperone Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Tissue Homeostasis
Chondrocyte Differentiation
Aortic Valve Morphogenesis
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Smoothened Signaling Pathway
Ras Protein Signal Transduction
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Glial Cell Proliferation
Cell Differentiation
Neuron Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Heterochromatin Formation
Developmental Process
Cellular Response To Insulin Stimulus
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Negative Regulation Of Glial Cell Proliferation
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
MRNA Splicing, Via Spliceosome
MRNA Processing
Protein Folding
Autophagy
Response To Unfolded Protein
Signal Transduction
RNA Splicing
Cellular Response To Starvation
Negative Regulation Of Signal Transduction
Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Protein Stability
Cellular Response To Stress
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of DNA-templated Transcription
ATP Metabolic Process
Negative Regulation Of Cellular Component Organization
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Cellular Response To Steroid Hormone Stimulus
Clathrin Coat Disassembly
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Nuclear events stimulated by ALK signaling in cancer
Positive Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Respiratory syncytial virus genome transcription
PKR-mediated signaling
Drugs
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Diseases
Chronic myeloid leukemia (CML)
Breast cancer
Osteosarcoma
Hepatocellular carcinoma
Small cell lung cancer
Esophageal cancer
Glioma
Bladder cancer
GWAS
Birth weight (
27680694
31043758
)
Chronic kidney disease (
26420894
)
Diastolic blood pressure (
34074324
)
Lymphocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Serum metabolite levels (
33031748
)
Interacting Genes
194 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FOXM1
FRK
FZR1
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KEAP1
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCF1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB1
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PPP1R9B
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIM28
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
92 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DPP3
DYNLL1
EGFR
ERBB3
ERH
ESR1
FANCC
FBP1
FNDC3B
FOXP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
NEDD8
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
RNF26
SAYSD1
SIRPA
SNCA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
USP40
VHL
WEE2-AS1
YWHAG
YWHAQ
Entrez ID
5925
3312
HPRD ID
01574
07205
Ensembl ID
ENSG00000139687
ENSG00000109971
Uniprot IDs
A0A2R8YFL6
A0A3B3IS71
P06400
P11142
Q53HF2
V9HW22
PDB IDs
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
9DGK
9DHC
9DHF
9DHU
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
6ZYJ
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Cellular Response To Stress
Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
DNA Damage Response
Chromatin
Chromatin Binding
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Programmed Cell Death
DNA-templated Transcription
Regulation Of Apoptotic Process
Macromolecule Metabolic Process
Chromatin Remodeling
Chromatin Organization
Regulation Of Mitotic Cell Cycle
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
DNA Binding
Transcription Cis-regulatory Region Binding
Nucleobase-containing Compound Metabolic Process
Response To Stress
Ubiquitin Protein Ligase Binding
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Folding
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Protein Stabilization
Negative Regulation Of Apoptotic Process
Enzyme Binding
Response To Stress
Negative Regulation Of Programmed Cell Death
Cytosol
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Cell Death
Positive Regulation Of Programmed Cell Death
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Primary Metabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Heat Shock Protein Binding
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Hsp70 Protein Binding
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Folding Chaperone Complex
Negative Regulation Of Intracellular Signal Transduction
Response To Heat
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Nucleus
Response To Peptide
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?