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RB1 and POLA1
Number of citations of the paper that reports this interaction (PMID
9395244
)
10
Data Source:
BioGRID
(affinity chromatography technology, biochemical)
HPRD
(in vivo, in vitro)
RB1
POLA1
Gene Name
retinoblastoma 1
polymerase (DNA directed), alpha 1, catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Spindle
SWI/SNF Complex
PML Body
Rb-E2F Complex
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytoplasm
Nuclear Matrix
Molecular Function
Core Promoter Binding
RNA Polymerase II Activating Transcription Factor Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Androgen Receptor Binding
Phosphoprotein Binding
Nucleotide Binding
Nucleoside Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
DNA Primase Activity
Protein Binding
Protein Kinase Binding
Metal Ion Binding
Protein Heterodimerization Activity
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Cell Cycle Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Chromatin Remodeling
Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Cell Cycle Arrest
Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis
Mitotic Cell Cycle Checkpoint
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Viral Process
Androgen Receptor Signaling Pathway
Sister Chromatid Biorientation
Neuron Projection Development
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Negative Regulation Of Epithelial Cell Proliferation
Striated Muscle Cell Differentiation
Cell Division
Neuron Apoptotic Process
Protein Localization To Chromosome, Centromeric Region
Regulation Of Cohesin Localization To Chromatin
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Proliferation
Viral Process
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
E2F mediated regulation of DNA replication
DNA Damage/Telomere Stress Induced Senescence
Synthesis of DNA
Mitotic Prophase
Cellular Senescence
G1 Phase
Regulation of DNA replication
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Orc1 removal from chromatin
S Phase
Cyclin E associated events during G1/S transition
Cell Cycle, Mitotic
M Phase
Orc1 removal from chromatin
Cyclin D associated events in G1
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
G1/S Transition
Removal of licensing factors from origins
Cyclin A:Cdk2-associated events at S phase entry
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Condensation of Prophase Chromosomes
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Activation of the pre-replicative complex
Extension of Telomeres
Activation of the pre-replicative complex
Leading Strand Synthesis
DNA strand elongation
Polymerase switching
DNA replication initiation
Telomere Maintenance
G1/S Transition
G1/S-Specific Transcription
Mitotic G1-G1/S phases
E2F mediated regulation of DNA replication
Polymerase switching on the C-strand of the telomere
Chromosome Maintenance
Telomere C-strand synthesis initiation
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the lagging strand
DNA Replication Pre-Initiation
M/G1 Transition
Telomere C-strand (Lagging Strand) Synthesis
S Phase
Cell Cycle, Mitotic
Removal of the Flap Intermediate
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Protein-Protein Interactions
167 interactors:
AATF
ABL1
AHR
AR
ARID3B
ATF2
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX1
CBX4
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CREG1
CTBP1
CUX1
DGKZ
DNMT1
DNMT3A
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FOS
FRK
GNB2L1
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
L3MBTL1
LIN54
LIN9
LMNA
MAPK1
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCOA6
NDC80
NEFM
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RAF1
RBAK
RBBP4
RBBP5
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF40
RUNX2
SERPINB2
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
SUMO1
SUMO2
SUV39H1
SUV420H2
TAF1
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIP11
UBE2I
UBTF
UHRF2
USP4
USP7
VDR
ZBTB16
17 interactors:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
RB1
RBMS1
SERPINA3
SMC1A
TP53
XRCC5
Entrez ID
5925
5422
HPRD ID
01574
02416
Ensembl ID
ENSG00000139687
ENSG00000101868
Uniprot IDs
P06400
A6NMQ1
P09884
PDB IDs
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4ELJ
4ELL
1K0P
1K18
1N5G
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Cell Cycle
RNA Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Gene Expression
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Cellular Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Modification
Cellular Response To Stress
Cell Cycle Process
Chromatin Organization
Mitotic Cell Cycle Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromosome Organization
Cellular Response To DNA Damage Stimulus
Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
DNA Metabolic Process
DNA Replication
Chromosome Organization
Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
DNA-dependent DNA Replication
Cell Cycle Checkpoint
Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Checkpoint
Cellular Response To DNA Damage Stimulus
Nucleobase-containing Compound Metabolic Process
DNA Repair
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Organelle Organization
Negative Regulation Of Mitotic Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Stress
Regulation Of Cell Cycle Process
Nitrogen Compound Metabolic Process
DNA Conformation Change
Positive Regulation Of Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Mitotic Nuclear Division
Regulation Of Cell Cycle
Telomere Maintenance
Cell Division
Regulation Of Mitotic Cell Cycle Phase Transition
Ras Protein Signal Transduction
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Damage Checkpoint
Nuclear DNA Replication
Mitotic DNA Integrity Checkpoint
Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
Positive Regulation Of Mitotic Cell Cycle
DNA Strand Elongation
G2/M Transition Of Mitotic Cell Cycle
DNA Replication Initiation
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Tagcloud
?
13q14
16q22
18q21
1p35
22p
22q
3p22
5q21
8p
9p21
apc
cent
crc
crcs
dcc
dukes
existed
frequencies
heterozygosity
loh
microsatellite
pairwise
q14
q22
rer
sporadic
ucacrc
ucacrcs
ulcerative
Tagcloud (Difference)
?
13q14
16q22
18q21
1p35
22p
22q
3p22
5q21
8p
9p21
apc
cent
crc
crcs
dcc
dukes
existed
frequencies
heterozygosity
loh
microsatellite
pairwise
q14
q22
rer
sporadic
ucacrc
ucacrcs
ulcerative
Tagcloud (Intersection)
?