KEAP1 and CAT

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KEAP1	CAT
Gene Name		kelch-like ECH-associated protein 1	catalase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding	Aminoacylase Activity Catalase Activity Receptor Binding Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration UV Protection Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Vitamin E Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Tetramerization Protein Homotetramerization Positive Regulation Of Cell Division Nucleobase-containing Small Molecule Metabolic Process Response To Hyperoxia Cellular Response To Growth Factor Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Purine catabolism Purine metabolism Detoxification of Reactive Oxygen Species Metabolism of nucleotides
Drugs			Fomepizole Heme
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	8 interactors: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10
Entrez ID		9817	847
HPRD ID		12079	00282
Ensembl ID		ENSG00000079999	ENSG00000121691
Uniprot IDs		Q14145	P04040
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Secretion Collateral Sprouting Neuromuscular Process Controlling Balance Bergmann Glial Cell Differentiation Innate Immune Response Neuron Remodeling Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Axon Guidance Regulation Of Protein Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Axonogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Axon Development Immune Response Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Defense Response Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Protein Transport Regulation Of Secretion Neuron Projection Morphogenesis Negative Regulation Of Cell Adhesion Regulation Of Establishment Of Protein Localization Neuron Maturation Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Brain Development Peptidyl-tyrosine Autophosphorylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Positive Regulation Of Oxidoreductase Activity Regulation Of Protein Localization Head Development Astrocyte Differentiation Neuron Projection Development Positive Regulation Of Cell Cycle Cell Projection Morphogenesis Cellular Calcium Ion Homeostasis
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	alternatives chloramphenicol competition constructs designated electrophoretic element emsa exactly flanking gggaaggcggagtcc ggrgyyn ifn inducibility inducible isre kcs mutagenesis mutational nnrrrgg pkr possessing purine pyrimidine replaced stands tata transfection whereby
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	alternatives chloramphenicol competition constructs designated electrophoretic element emsa exactly flanking gggaaggcggagtcc ggrgyyn ifn inducibility inducible isre kcs mutagenesis mutational nnrrrgg pkr possessing purine pyrimidine replaced stands tata transfection whereby
Tagcloud (Intersection) ?