KEAP1 and AK4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KEAP1	AK4
Gene Name		kelch-like ECH-associated protein 1	adenylate kinase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Liver Development Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Brain Development Nucleoside Triphosphate Biosynthetic Process Response To Drug AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	4 interactors: APP CEP19 EPHA8 KEAP1
Entrez ID		9817	205
HPRD ID		12079	00048
Ensembl ID		ENSG00000079999	ENSG00000162433
Uniprot IDs		Q14145	P27144
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK	2AR7 2BBW 3NDP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Neuron Remodeling Neuron Maturation Cell Maturation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Proteolysis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Axon Guidance Positive Regulation Of Cellular Metabolic Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cellular Copper Ion Homeostasis Regulation Of Proteolysis Cellular Protein Modification Process Cell Morphogenesis Involved In Differentiation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Kinase Activity Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Activity MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Projection Morphogenesis Cell Part Morphogenesis Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Substrate-dependent Cell Migration Neuron Recognition Neuron Development Cellular Response To Interleukin-4 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Epidermal Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Morphogenesis Regulation Of Cell Cycle G2/M Phase Transition Response To Interleukin-4 Cellular Protein Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Activity
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	abolished adenocarcinoma adenylate advanced aggressive assist atf3 biomarkers invasion invasive limits lung mechanistically metastasis metastatic microarray overexpressing overexpression pivotal predicting promoted promotes promoting published recurrence simultaneous suppressed unfavorable upregulated
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	abolished adenocarcinoma adenylate advanced aggressive assist atf3 biomarkers invasion invasive limits lung mechanistically metastasis metastatic microarray overexpressing overexpression pivotal predicting promoted promotes promoting published recurrence simultaneous suppressed unfavorable upregulated
Tagcloud (Intersection) ?