KEAP1 and MYO7A

Number of citations of the paper that reports this interaction (PMID 11921171)
21

Data Source:
HPRD (in vivo, two hybrid)

		KEAP1	MYO7A
Gene Name		kelch-like ECH-associated protein 1	myosin VIIA
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cell Cortex Apical Plasma Membrane Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse
	Molecular Function	Protein Binding Transcription Factor Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Protein Homodimerization Activity ADP Binding Actin Filament Binding
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Phagolysosome Assembly Intracellular Protein Transport Lysosome Organization Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Eye Photoreceptor Cell Development Post-embryonic Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Diseases associated with visual transduction
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	11 interactors: ACTA1 CALM1 CDH23 DFNB31 KEAP1 KHDRBS1 MAP2 MYRIP PRKAR1A USH1C VEZT
Entrez ID		9817	4647
HPRD ID		12079	02043
Ensembl ID		ENSG00000079999	ENSG00000137474
Uniprot IDs		Q14145	B9A012 Q13402
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Retina Homeostasis Equilibrioception Sensory Perception Of Sound Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus Tissue Homeostasis Photoreceptor Cell Maintenance Multicellular Organismal Homeostasis Multicellular Organismal Development Activation Of Phospholipase C Activity Anatomical Structure Development Positive Regulation Of Phospholipase C Activity Inner Ear Receptor Cell Differentiation Mechanoreceptor Differentiation Myofibril Assembly Positive Regulation Of Phospholipase Activity Neuromuscular Process Controlling Balance Developmental Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Positive Regulation Of RNA Export From Nucleus Skeletal Muscle Fiber Adaptation Parallel Actin Filament Bundle Assembly Actomyosin Structure Organization Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Embryo Development G2/M Transition Of Mitotic Cell Cycle Neuromuscular Process Positive Regulation Of Protein Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Striated Muscle Cell Development Regulation Of High Voltage-gated Calcium Channel Activity Actin Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Muscle Cell Development Fibroblast Growth Factor Receptor Signaling Pathway Homeostatic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Actin Filament-based Process Skeletal Muscle Thin Filament Assembly Inner Ear Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Organic Substance Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	11q13 15q21 1e aas admixture african americans ancestry caucasian causation chr15q21 cytoskeleton dermal descent exome genotyping gwas japanese keloid keloids mapping migratory myo1e myosin nedd4 peaks predisposition rs35641839 sporadically
Tagcloud (Intersection) ?