RB1 and LMNA

Number of citations of the paper that reports this interaction (PubMedID 8278403)
40

Data Source:
HPRD (in vitro)

		RB1	LMNA
Description		RB transcriptional corepressor 1	lamin A/C
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Spindle Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex SWI/SNF Complex PML Body Rb-E2F Complex Chromatin Lock Complex	Nucleus Nuclear Envelope Lamin Filament Nuclear Lamina Nucleoplasm Cytosol Intermediate Filament Nuclear Matrix Nuclear Speck Nuclear Membrane Nuclear Lumen Site Of Double-strand Break Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding Structural Constituent Of Nuclear Lamina
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Tissue Homeostasis Chondrocyte Differentiation Aortic Valve Morphogenesis Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Protein Kinase Activity Apoptotic Process Smoothened Signaling Pathway Ras Protein Signal Transduction Spermatogenesis Regulation Of Mitotic Cell Cycle Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Glial Cell Proliferation Cell Differentiation Neuron Differentiation Negative Regulation Of Cell Growth Sister Chromatid Biorientation Neuron Projection Development Heterochromatin Formation Developmental Process Cellular Response To Insulin Stimulus Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Striated Muscle Cell Differentiation Chromosome Organization Cell Division Neuron Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Glial Cell Proliferation Protein Localization To Chromosome, Centromeric Region Cellular Response To Xenobiotic Stimulus Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Myofibroblast Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway	Protein Import Into Nucleus Nucleus Organization Nuclear Envelope Organization Nuclear Migration Muscle Organ Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Heterochromatin Formation Regulation Of Protein Stability Regulation Of Telomere Maintenance Protein Localization To Nucleus Nuclear Pore Localization Ventricular Cardiac Muscle Cell Development Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Senescence Protein Localization To Nuclear Envelope Regulation Of Protein Localization To Nucleus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress DNA Double-strand Break Attachment To Nuclear Envelope Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome Nuclear events stimulated by ALK signaling in cancer Positive Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	XBP1(S) activates chaperone genes Signaling by BRAF and RAF1 fusions
Drugs
Diseases		Chronic myeloid leukemia (CML) Breast cancer Osteosarcoma Hepatocellular carcinoma Small cell lung cancer Esophageal cancer Glioma Bladder cancer	Mandibuloacral dysplasia Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Hutchinson-Gilford progeria syndrome Restrictive dermopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Birth weight ( 27680694 31043758) Chronic kidney disease ( 26420894) Diastolic blood pressure ( 34074324) Lymphocyte count ( 32888494) Offspring birth weight ( 31043758) Post bronchodilator FEV1/FVC ratio ( 26634245)	Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip index ( 34021172) Ischemic heart disease in rheumatoid arthritis ( 30251476) Lung cancer in ever smokers ( 28604730) Monocyte count ( 32888494) Neutrophil count ( 32888494) Ovarian cancer ( 30557369) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		194 interacting genes: AATF ABL1 AHR ANKS1A AR ARID3B ATF2 BAAT BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX4 CCDC180 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CHN2 CLNK CORO2A CREG1 CTBP1 CTSV CUX1 DGKZ DNMT1 DVL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FANCC FBP1 FBP2 FOS FOXM1 FRK FZR1 GALNT12 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B KEAP1 KMT5C L3MBTL1 LEF1 LIN54 LIN9 LMNA MAPK1 MAPK14 MAPK3 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCF1 NCOA6 NDC80 NEFM ORC1 PA2G4 PAX2 PAX5 PAX6 PELP1 PHB1 PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PPP1R26 PPP1R9B PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RABGAP1L RACK1 RAF1 RASA1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF123 RNF40 RUNX2 SERPINB2 SHC1 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 STX17 SUV39H1 TAF1 TASOR TBP TFAP2A TGM2 THOC1 TMPO TOP2A TRAP1 TRIM27 TRIM28 TRIP11 TRMO UBE2I UBTF USP4 USP7 VDR XPA ZBTB16	381 interacting genes: ABCA9 ACOT7 ACTB ADAM33 ADGRE2 ADGRG7 AGTRAP AIG1 AKTIP ALG3 ALG8 ALOX12 ALOX12B ANKRD20A5P ANXA1 AOC3 APOA2 APOD APOL2 AQP1 AQP10 AQP3 ARHGEF16 ARL6IP1 ARLN ASGR1 ATP6V0C BCL2L2 BNIP2 BNIP3 BNIP3L BRICD5 BTN2A2 BYSL C11orf24 C1QTNF1 C20orf141 C3orf52 C5 CACNG1 CASP1 CASP6 CCDC120 CCNG1 CD52 CD72 CD81 CDK1 CDS2 CENPP CETN3 CFHR5 CHST1 CLCA4 CLDN10 CLDND2 CLEC1A CLEC4A CLK1 CLN6 CMTM3 CMTM5 CMTM7 CNIH3 COL8A2 COX14 CREB3 CRY2 CSGALNACT2 CTSA CWF19L2 CXCL14 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 CYBRD1 DBNDD2 DDX24 DDX43 DEFB127 DERL1 DERL2 DNAJC30 DUS3L DUSP13B EDDM3B EGF EIF3G EIF4ENIF1 ELOA EMD ENTPD3 ERG28 F2RL1 FA2H FAIM FAM161A FAM3C FAM9B FATE1 FAXDC2 FBXO7 FCER1A FCER1G FDFT1 FETUB FLNA FOS FXYD3 FXYD6 GALNT2 GIN1 GJB2 GJB5 GOLGA2P10 GOLT1B GOSR2 GPR108 GPR25 GRM2 GZMA GZMB HACD1 HCK HMOX1 IFFO1 IFIT2 IGFBP5 INSIG2 ITGAM ITM2B IZUMO2 JAGN1 KASH5 KAT5 KCNK1 KCNK13 KIF12 KPNA6 KRT6A KRTAP10-3 KRTAP10-7 LAMB1 LAT LCP2 LEPROTL1 LHFPL5 LIMS2 LINC01587 LMBR1 LMNB1 LPAR3 LRP10 LVRN MAL MALL MAPRE2 MARVELD1 MATR3 MCM5 MEOX1 MFAP1 MGLL MGST3 MIP MLIP MMD2 MORF4L1 MRPS26 MS4A1 MTHFD2 MUTYH MYADM NAB2 NALCN NARF NAT8 NEU1 NINJ2 NIPAL3 NKG7 NOD2 NTAQ1 OGT ORMDL1 ORMDL3 OSBPL8 OSTCP1 OSTF1 PAQR5 PARPBP PCBP1 PCGF2 PELI1 PERM1 PIAS2 PIK3R2 PKD2 PLLP PLP1 PLP2 PLPP4 PMP22 PNKP PNLIPRP1 PRELID3A PRKCA PRPF6 PTPN9 PYGM RABAC1 RANBP9 RB1 RBBP4 RBFOX2 REEP6 RGS18 RHAG RMDN2 RNF123 RPRM RTN1 RTN3 RTN4 RUSF1 SACM1L SBDS SCARA3 SCARB2 SEC22A SEC22B SELENOK SENP2 SERP1 SERP2 SERPINE1 SFT2D2 SFTPC SGMS2 SH3RF2 SIAH1 SLC13A3 SLC1A1 SLC26A4-AS1 SLC2A5 SLC30A2 SLC30A3 SLC30A8 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SLC7A1 SLN SLU7 SMAD1 SMAD3 SMCO4 SMIM11 SMURF1 SMURF2 SNORC SPANXC SPANXD SPG21 SPN SREBF1 SRPK2 STAC STAC2 STARD3 STX12 STX3 STX4 STX5 STX6 STX7 STX8 SUMO2 SUMO4 SVIL SYNE1 SYNGR1 SYPL1 SYT6 TAP1 TCEA2 TCEANC TDO2 TFIP11 TFRC THBD TM4SF20 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM14C TMEM201 TMEM203 TMEM208 TMEM218 TMEM222 TMEM230 TMEM234 TMEM243 TMEM267 TMEM41A TMEM42 TMEM43 TMEM51 TMEM54 TMEM60 TMEM65 TMEM74 TMEM86A TMPO TMPRSS4 TNF TNFRSF10C TNFSF12 TNMD TOR1A TOR1AIP1 TRAM1L1 TRIM26 TRIM39 TSGA10 TSNARE1 TSPAN2 TSPAN33 TSPAN7 UBE2I UBE2Q1 UBQLNL UCHL5 UNC13D UNC45A UNC50 UPK1B URB2 USE1 USP2 USP20 VAMP1 VAMP2 VAMP3 VAMP5 VKORC1 VMA12 VMP1 VSTM1 VTI1B WFDC2 YIPF1 YIPF6 YWHAQ ZC2HC1C ZDHHC15 ZDHHC24 ZMYM6 ZNF138 ZNF239 ZNF25 ZNF3 ZNF439 ZNF440 ZNF490 ZNF564 ZNF569 ZNF69 ZSCAN12
Entrez ID		5925	4000
HPRD ID		01574	01035
Ensembl ID		ENSG00000139687	ENSG00000160789
Uniprot IDs		A0A2R8YFL6 A0A3B3IS71 P06400	A0A384MQX1 H0YAB0 P02545 Q5TCI8
PDB IDs		1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL 9DGK 9DHC 9DHF 9DHU	1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B 6GHD 6JLB 6RPR 6SNZ 6YF5 6YJD 7CRG 7D9N 7WZZ 7X1B 7X5D 7YVD 7Z21 8I33 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Damage Response Chromatin Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death DNA-templated Transcription Regulation Of Apoptotic Process Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Mitotic Cell Cycle RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction DNA Binding Transcription Cis-regulatory Region Binding Nucleobase-containing Compound Metabolic Process Response To Stress	Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Protein Binding Membrane Organization SNARE Complex Endoplasmic Reticulum Nuclear Inner Membrane Endomembrane System SNARE Binding Lamin Binding Vesicle Fusion Membrane Fusion Organelle Membrane Fusion Vesicle Docking Intracellular Protein Localization Organelle Fusion Structural Constituent Of Myelin Sheath Organelle Localization By Membrane Tethering Nuclear Envelope Endoplasmic Reticulum Tubular Network Formation Membrane Docking Regulation Of Protein Localization Establishment Of Protein Localization Secretion By Cell Ascorbate Homeostasis Regulation Of Protein Localization To Plasma Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Leukocyte Degranulation Regulation Of Protein Localization To Membrane Protein Transport Transmembrane Monodehydroascorbate Reductase Activity Respiratory Burst After Phagocytosis Golgi Membrane Regulation Of Protein Localization To Cell Periphery Myelination Regulation Of Cellular Localization Vesicle Recycling Endosome Axon Ensheathment Endoplasmic Reticulum Tubular Network Organization Defense Response Positive Regulation Of Transport Regulation Of Transport Identical Protein Binding Vesicle-mediated Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Nuclear Membrane Organization SNARE Complex Assembly Intracellular Sphingolipid Homeostasis
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