KEAP1 and BPTF

Number of citations of the paper that reports this interaction (PMID 15379550)
8

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid, in vitro)

		KEAP1	BPTF
Gene Name		kelch-like ECH-associated protein 1	bromodomain PHD finger transcription factor
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm NURF Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding	Protein Binding DNA-dependent ATPase Activity Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Brain Development Endoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 22797724) Lung cancer ( 23143601)
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	9 interactors: H3F3A HIST1H4I HIST3H3 KEAP1 MAZ NFE2L2 SMAD2 SMAD3 SQSTM1
Entrez ID		9817	2186
HPRD ID		12079	03490
Ensembl ID		ENSG00000079999	ENSG00000171634
Uniprot IDs		Q14145	Q12830
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK	2F6J 2F6N 2FSA 2FUI 2FUU 2RI7 3QZS 3QZT 3QZV 3UV2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Gene Silencing Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Gene Expression, Epigenetic Primary MiRNA Processing SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Nodal Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Embryonic Foregut Morphogenesis Foregut Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Paraxial Mesoderm Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Pericardium Development Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecular Complex Assembly Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Chromatin Silencing DNA Replication-independent Nucleosome Assembly Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Posttranscriptional Gene Silencing Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Embryonic Cranial Skeleton Morphogenesis DNA Methylation
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	13q33 col4a1 col4a2 d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg	13q33 col4a1 col4a2 d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants
Tagcloud (Intersection) ?