KEAP1 and IPO11

Number of citations of the paper that reports this interaction (PubMedID 21383067)
50

Data Source:
BioGRID (pull down)

		KEAP1	IPO11
Description		kelch like ECH associated protein 1	importin 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Protein-containing Complex Centriolar Satellite	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Cell Differentiation Protein K48-linked Ubiquitination Cellular Response To Interleukin-4 Negative Regulation Of Response To Oxidative Stress	Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport
Pathways		Ub-specific processing proteases Neddylation Potential therapeutics for SARS KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dimethyl fumarate
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Alcohol and nicotine co-dependence ( 23216389) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) General risk tolerance (MTAG) ( 30643258) Interstitial lung abnormalities ( 31339356) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma selenium concentration ( 33382417) Subpleural-predominant interstitial lung abnormalities ( 31339356)
Interacting Genes		93 interacting genes: AK4 AMER1 ANKS1A ASTN1 ATF5 ATG5 BAD BPTF BTRC C2orf68 C6orf132 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DDRGK1 EAF1 EGFR ERICH5 ETF1 FAM117B FBXL17 FXR1 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL24 KPNA6 LAMC1 LAMTOR5 LINC00239 LSM3 MAD2L1 MAPKBP1 MCC MCMBP MLST8 MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PAK1 PAQR4 PDCD6IP PLEC PRKAG1 PTMA PTTG1 RAF1 RB1 RBX1 RECK RELA RNF26 SGCE SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRERF1 TRIM15 TRIM59 UBC UBE2D1 USP15 WDR83 WHRN ZNF121 ZSCAN32	14 interacting genes: C1orf94 CEBPA EIF4A2 KEAP1 KRT76 NXF1 PLCD4 RAN RNF10 RPL12 TRAF2 UBE2E1 UBE2E2 UBE2E3
Entrez ID		9817	51194
HPRD ID		12079	10003
Ensembl ID		ENSG00000079999	ENSG00000086200
Uniprot IDs		Q14145	Q9UI26
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A 7EXI 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2F 7K2G 7K2H 7K2I 7K2J 7K2K 7K2L 7K2M 7K2N 7K2O 7K2P 7K2Q 7K2R 7K2S 7Q5H 7Q6Q 7Q6S 7Q8R 7Q96 7X4W 7X4X 7XM2 7XM3 7XM4 7XM5 7XOT 8EHV 8EJR 8EJS 8IVG 8IVR 8IXS 8PKS 8PKU 8PKV 8PKW 8PKX 8WFG 8X34 8XGK 8XGV 9DU7 9ETX 9ETY
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Negative Regulation Of Catabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Catabolic Process Response To Oxygen Levels Positive Regulation Of Biosynthetic Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Autophagy Import Into Nucleus Negative Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Programmed Cell Death Regulation Of Type I Interferon Production	Protein Monoubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation ISG15-protein Conjugation Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA-dependent RNA Polymerase Activity Protein Metabolic Process TORC2 Complex Disassembly Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Protein Modification Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Autoubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Export From Nucleus Nuclear Pore
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?