RB1 and MDM4

Number of citations of the paper that reports this interaction (PMID 16510145)
2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RB1	MDM4
Gene Name		retinoblastoma 1	MDM4, p53 regulator
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spindle SWI/SNF Complex PML Body Rb-E2F Complex	Nucleus Nucleoplasm
	Molecular Function	Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Androgen Receptor Binding Phosphoprotein Binding	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromatin Remodeling Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Viral Process Androgen Receptor Signaling Pathway Sister Chromatid Biorientation Neuron Projection Development Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Striated Muscle Cell Differentiation Cell Division Neuron Apoptotic Process Protein Localization To Chromosome, Centromeric Region Regulation Of Cohesin Localization To Chromatin Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process G0 To G1 Transition Protein Stabilization Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia
Pathways		E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Mitotic Prophase Cellular Senescence G1 Phase Regulation of DNA replication Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Orc1 removal from chromatin S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic M Phase Orc1 removal from chromatin Cyclin D associated events in G1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) G1/S Transition Removal of licensing factors from origins Cyclin A:Cdk2-associated events at S phase entry Switching of origins to a post-replicative state Mitotic G1-G1/S phases Condensation of Prophase Chromosomes Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS			Breast cancer ( 23535733) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Prostate cancer ( 23535732)
Protein-Protein Interactions		167 interactors: AATF ABL1 AHR AR ARID3B ATF2 BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX1 CBX4 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CREG1 CTBP1 CUX1 DGKZ DNMT1 DNMT3A DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FOS FRK GNB2L1 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B L3MBTL1 LIN54 LIN9 LMNA MAPK1 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCOA6 NDC80 NEFM PA2G4 PAX2 PAX5 PAX6 PELP1 PHB PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RAF1 RBAK RBBP4 RBBP5 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF40 RUNX2 SERPINB2 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 SUMO1 SUMO2 SUV39H1 SUV420H2 TAF1 TBP TFAP2A TGM2 THOC1 TMPO TOP2A TRAP1 TRIM27 TRIP11 UBE2I UBTF UHRF2 USP4 USP7 VDR ZBTB16	42 interactors: AKT1 APP ARF1 ATM CAPN7 CASP3 CD160 CDK1 CHEK1 CHEK2 CSNK1A1 E2F1 EP300 LRSAM1 MDM2 MKRN3 MNAT1 PRKAA1 RAD54B RB1 RN5S1@ RNF115 SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5925	4194
HPRD ID		01574	04082
Ensembl ID		ENSG00000139687	ENSG00000198625
Uniprot IDs		P06400	O15151 Q59FS6 Q68DC0
PDB IDs		1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4ELJ 4ELL	2CR8 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3U15
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Cellular Response To Stress Cell Cycle Process Chromatin Organization Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cellular Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Response To Abiotic Stimulus Cellular Response To Stress Cell Cycle Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Hypoxia Intracellular Signal Transduction Cellular Response To Decreased Oxygen Levels Response To Hypoxia Positive Regulation Of Cell Death Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Cellular Response To Oxygen Levels Response To Stress Regulation Of Cell Death Cellular Response To Stimulus Regulation Of Intracellular Transport Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Signal Transduction Regulation Of Cellular Component Organization Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction
Tagcloud ?		13q14 16q22 18q21 1p35 22p 22q 3p22 5q21 8p 9p21 apc cent crc crcs dcc dukes existed frequencies heterozygosity loh microsatellite pairwise q14 q22 rer sporadic ucacrc ucacrcs ulcerative	aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb rb1 reactivating reactivation reporting summary targeting video
Tagcloud (Difference) ?		13q14 16q22 18q21 1p35 22p 22q 3p22 5q21 8p 9p21 apc cent crc crcs dcc dukes existed frequencies heterozygosity loh microsatellite pairwise q14 q22 rer sporadic ucacrc ucacrcs ulcerative	aberrations abstract along attractive cdk cdk4 checkpoint correlate cyclind developments entered highlights kinases logical make maximizing mdm2 melanoma melanomagenesis p16 preliminary rb reactivating reactivation reporting summary targeting video
Tagcloud (Intersection) ?		rb1