KEAP1 and AMER1

Number of citations of the paper that reports this interaction (PMID 22215675)
8

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		KEAP1	AMER1
Gene Name		kelch-like ECH-associated protein 1	APC membrane recruitment protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Nucleus Cytosol Plasma Membrane
	Molecular Function	Protein Binding Transcription Factor Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Beta-catenin Binding
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Wnt Signaling Pathway Bone Development Adipose Tissue Development Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Differentiation Involved In Kidney Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	5 interactors: AXIN1 BTRC CTNNB1 FBXW11 KEAP1
Entrez ID		9817	139285
HPRD ID		12079	06565
Ensembl ID		ENSG00000079999	ENSG00000184675
Uniprot IDs		Q14145	Q5JTC6
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Wnt Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Polyubiquitination Embryonic Skeletal Joint Morphogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Embryonic Skeletal Joint Development Positive Regulation Of Circadian Rhythm Dorsal/ventral Axis Specification Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity In Utero Embryonic Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Ligase Activity Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Intracellular Signal Transduction Canonical Wnt Signaling Pathway
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Intersection) ?