KEAP1 and DDRGK1

Number of citations: 56 (PubMedID 36965071)
Data Source: BioGRID (pull down, pull down)

		KEAP1	DDRGK1
Name		kelch like ECH associated protein 1	DDRGK domain containing 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Protein-containing Complex Centriolar Satellite	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Ubiquitin-like Protein Ligase Binding UFM1-modified Protein Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Regulation Of Autophagy Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Epidermal Cell Differentiation Protein K48-linked Ubiquitination Cellular Response To Interleukin-4 Negative Regulation Of Response To Oxidative Stress	Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Reticulophagy Protein Localization To Endoplasmic Reticulum Protein Ufmylation Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum Protein K69-linked Ufmylation
Pathways		Ub-specific processing proteases Neddylation Potential therapeutics for SARS KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation	RHOA GTPase cycle
Drugs		Dimethyl fumarate	None
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483 ) Body mass index and systolic blood pressure (bivariate analysis) ( 33539483 ) Body mass index and waist-hip ratio (pleiotropy) ( 29868124 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )	HDL cholesterol levels x loop diuretics use interaction ( 31806883 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Night sleep phenotypes ( 27126917 ) Parkinson's disease ( 25064009 28892059 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Response to hepatitis C treatment ( 21659334 ) Ribavirin-induced anemia ( 20637204 )
Interacting Genes		93 interacting genes: AK4 AMER1 ANKS1A ASTN1 ATF5 ATG5 BAD BPTF BTRC C2orf68 C6orf132 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN DDRGK1 EAF1 EGFR ERICH5 ETF1 FAM117B FBXL17 FXR1 GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL12 KLHL24 KPNA6 LAMC1 LAMTOR5 LINC00239 LSM3 MAD2L1 MAPKBP1 MCC MCMBP MLST8 MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PAK1 PAQR4 PDCD6IP PLEC PRKAG1 PTMA PTTG1 RAF1 RB1 RBX1 RECK RELA RNF26 SGCE SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRERF1 TRIM15 TRIM59 UBC UBE2D1 USP15 WDR83 WHRN ZNF121 ZSCAN32	6 interacting genes: APP CFTR FBXO7 HTR6 KEAP1 TP53
Entrez ID		9817	65992
HPRD ID		12079	12741
Ensembl ID		ENSG00000079999	ENSG00000198171
Uniprot IDs		Q14145	Q96HY6
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ 6Z6A 7EXI 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2F 7K2G 7K2H 7K2I 7K2J 7K2K 7K2L 7K2M 7K2N 7K2O 7K2P 7K2Q 7K2R 7K2S 7Q5H 7Q6Q 7Q6S 7Q8R 7Q96 7X4W 7X4X 7XM2 7XM3 7XM4 7XM5 7XOT 8EHV 8EJR 8EJS 8IVG 8IVR 8IXS 8PKS 8PKU 8PKV 8PKW 8PKX 8WFG 8X34 8XGK 8XGV 9DU7 9ETX 9ETY	7W3N 8B9X 8C0D 8OHD 8OJ0 8OJ5
GO Terms Enriched among Interactors		Identical Protein Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Catabolic Process Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Modification By Small Protein Conjugation Regulation Of Protein Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Protein Modification Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Regulation Of Protein Ubiquitination Negative Regulation Of Catabolic Process Post-translational Protein Modification Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Protein Catabolic Process Response To Oxygen Levels Positive Regulation Of Biosynthetic Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Autophagy Import Into Nucleus Negative Regulation Of Apoptotic Signaling Pathway Response To Hypoxia Programmed Cell Death Regulation Of Type I Interferon Production	Protein-containing Complex Protein-folding Chaperone Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Molecular Function Activator Activity Disordered Domain Specific Binding 14-3-3 Protein Binding Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Enzyme Binding Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Protein Heterodimerization Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Autophagy Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process Response To CAMP Protein Tetramerization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Developmental Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium