RB1 and MYC

Number of citations of the paper that reports this interaction (PMID 7838535)
2

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		RB1	MYC
Gene Name		retinoblastoma 1	v-myc avian myelocytomatosis viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Spindle SWI/SNF Complex PML Body Rb-E2F Complex	Nucleus Nucleoplasm Nucleolus Cytosol Protein Complex
	Molecular Function	Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Androgen Receptor Binding Phosphoprotein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding
	Biological Process	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromatin Remodeling Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Viral Process Androgen Receptor Signaling Pathway Sister Chromatid Biorientation Neuron Projection Development Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Striated Muscle Cell Differentiation Cell Division Neuron Apoptotic Process Protein Localization To Chromosome, Centromeric Region Regulation Of Cohesin Localization To Chromatin Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Positive Regulation Of Cell Proliferation Response To Gamma Radiation Gene Expression Regulation Of Gene Expression Oxygen Transport Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus
Pathways		E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Mitotic Prophase Cellular Senescence G1 Phase Regulation of DNA replication Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Orc1 removal from chromatin S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic M Phase Orc1 removal from chromatin Cyclin D associated events in G1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) G1/S Transition Removal of licensing factors from origins Cyclin A:Cdk2-associated events at S phase entry Switching of origins to a post-replicative state Mitotic G1-G1/S phases Condensation of Prophase Chromosomes Inhibition of replication initiation of damaged DNA by RB1/E2F1	Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt Cyclin E associated events during G1/S transition binding of TCF/LEF:CTNNB1 to target gene promoters TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mitotic G1-G1/S phases FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer S Phase Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT Signaling by NOTCH1 PEST Domain Mutants in Cancer Cyclin A:Cdk2-associated events at S phase entry Signaling by WNT in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Bladder cancer ( 20972438) Breast cancer ( 23535729) Colorectal cancer ( 23266556) Multiple sclerosis ( 21833088) Ovarian cancer ( 23535730 20852632) Urinary bladder cancer ( 20348956 18794855)
Protein-Protein Interactions		167 interactors: AATF ABL1 AHR AR ARID3B ATF2 BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX1 CBX4 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CREG1 CTBP1 CUX1 DGKZ DNMT1 DNMT3A DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FOS FRK GNB2L1 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B L3MBTL1 LIN54 LIN9 LMNA MAPK1 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCOA6 NDC80 NEFM PA2G4 PAX2 PAX5 PAX6 PELP1 PHB PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RAF1 RBAK RBBP4 RBBP5 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF40 RUNX2 SERPINB2 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 SUMO1 SUMO2 SUV39H1 SUV420H2 TAF1 TBP TFAP2A TGM2 THOC1 TMPO TOP2A TRAP1 TRIM27 TRIP11 UBE2I UBTF UHRF2 USP4 USP7 VDR ZBTB16	126 interactors: ACTL6A ATAD2 AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CCNH CCNT1 CDC6 CDCA7L CDK1 CDK4 CDK6 CDK8 CDKN2A CEBPA CEBPB CEP57 CREB1 CREBBP CSNK2A1 CSNK2A2 DNMT3A EFNB1 ELF3 EP300 EP400 FBXO8 FBXW7 FBXW8 GCN1L1 GPX2 GSK3A GSK3B GTF2B GTF2F1 GTF2I HNRNPD HSP90AA1 HUWE1 ING4 KAT2A KAT2B KAT5 KDM1A KIAA1524 KIDINS220 KPNA2 LDOC1 MAP2K1 MAPK1 MAPK3 MAPK7 MAPK8 MAX MED1 MED12 MED14 MED16 MEN1 MINA MLH1 MOK MXD1 MXI1 MYCBP MYCBP2 NEK11 NFYB NFYC NMI NOTCH3 NUCB1 PAK2 PARP10 PFDN5 PLAU PML POLR2A PRDX1 PSMC3 RAF1 RB1 RBL1 RELA RUVBL1 SAP130 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SP1 SPAG9 SUPT3H TADA2A TAF1B TAF5 TAF9 TBP TFAP2A TFAP2B TIAM1 TONSL TP73 TRIM6 TRRAP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP37 YEATS4 YY1 ZBTB17 ZNF281
Entrez ID		5925	4609
HPRD ID		01574	01818
Ensembl ID		ENSG00000139687	ENSG00000136997
Uniprot IDs		P06400	P01106
PDB IDs		1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4ELJ 4ELL	1A93 1EE4 1MV0 1NKP 2A93 2OR9
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Cellular Response To Stress Cell Cycle Process Chromatin Organization Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cellular Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition	Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Regulation Of Cellular Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Negative Regulation Of Biosynthetic Process Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Gene Expression Cellular Response To Stress Mitotic Cell Cycle Histone Acetylation Negative Regulation Of Transcription, DNA-templated Chromatin Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation
Tagcloud ?		13q14 16q22 18q21 1p35 22p 22q 3p22 5q21 8p 9p21 apc cent crc crcs dcc dukes existed frequencies heterozygosity loh microsatellite pairwise q14 q22 rer sporadic ucacrc ucacrcs ulcerative	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		13q14 16q22 18q21 1p35 22p 22q 3p22 5q21 8p 9p21 apc cent crc crcs dcc dukes existed frequencies heterozygosity loh microsatellite pairwise q14 q22 rer sporadic ucacrc ucacrcs ulcerative	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?