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RB1 and PHB1
Number of citations of the paper that reports this interaction (PubMedID
10376528
)
0
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
RB1
PHB1
Description
RB transcriptional corepressor 1
prohibitin 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Spindle
Cytosol
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Chromatin Lock Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Early Endosome
Plasma Membrane
Cell Surface
Membrane
Mitochondrial Prohibitin Complex
Extracellular Exosome
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Complement Component C3a Binding
Complement Component C3b Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Proteinase Activated Receptor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Tissue Homeostasis
Chondrocyte Differentiation
Aortic Valve Morphogenesis
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Smoothened Signaling Pathway
Ras Protein Signal Transduction
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Glial Cell Proliferation
Cell Differentiation
Neuron Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Heterochromatin Formation
Developmental Process
Cellular Response To Insulin Stimulus
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Negative Regulation Of Glial Cell Proliferation
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Positive Regulation Of Immunoglobulin Production
Regulation Of DNA-templated Transcription
Mitochondrion Organization
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription By Competitive Promoter Binding
Negative Regulation Of Cell Growth
Positive Regulation Of Interleukin-17 Production
RIG-I Signaling Pathway
Epigenetic Regulation Of Gene Expression
B Cell Activation
Negative Regulation Of Protein Catabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Host-mediated Perturbation Of Viral RNA Genome Replication
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Complement Activation
Symbiont Entry Into Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Protein Stabilization
Progesterone Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-6
DNA Biosynthetic Process
T-helper 17 Type Immune Response
Antiviral Innate Immune Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Nuclear events stimulated by ALK signaling in cancer
Positive Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
RAF activation
Signaling by moderate kinase activity BRAF mutants
Paradoxical activation of RAF signaling by kinase inactive BRAF
Processing of SMDT1
Signaling downstream of RAS mutants
Drugs
Rocaglamide
Didesmethylrocaglamide
Diseases
Chronic myeloid leukemia (CML)
Breast cancer
Osteosarcoma
Hepatocellular carcinoma
Small cell lung cancer
Esophageal cancer
Glioma
Bladder cancer
GWAS
Birth weight (
27680694
31043758
)
Chronic kidney disease (
26420894
)
Diastolic blood pressure (
34074324
)
Lymphocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
194 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FOXM1
FRK
FZR1
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KEAP1
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCF1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB1
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PPP1R9B
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIM28
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
27 interacting genes:
ANXA2
BCAS3
CASC3
CCL5
CD40LG
COX6C
E2F1
ESR1
HDAC1
LONRF3
MAP1LC3A
MAP3K10
MCM2
NCOR1
PTEN
RAF1
RB1
RBL1
RBL2
SEC22A
SIN3A
SMARCA2
SMARCA4
ST14
SUMO4
TP53
XPO1
Entrez ID
5925
5245
HPRD ID
01574
01454
Ensembl ID
ENSG00000139687
ENSG00000167085
Uniprot IDs
A0A2R8YFL6
A0A3B3IS71
P06400
A8K401
P35232
Q53FV0
PDB IDs
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
9DGK
9DHC
9DHF
9DHU
8RRH
Enriched GO Terms of Interacting Partners
?
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Cellular Response To Stress
Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
DNA Damage Response
Chromatin
Chromatin Binding
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Programmed Cell Death
DNA-templated Transcription
Regulation Of Apoptotic Process
Macromolecule Metabolic Process
Chromatin Remodeling
Chromatin Organization
Regulation Of Mitotic Cell Cycle
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
DNA Binding
Transcription Cis-regulatory Region Binding
Nucleobase-containing Compound Metabolic Process
Response To Stress
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Transcription Regulator Complex
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Lipid Kinase Activity
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Organization
Chromatin
Regulation Of Primary Metabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Enzyme Binding
Regulation Of Gene Expression
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Negative Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Heterochromatin Formation
Rhythmic Process
Transcription Repressor Complex
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Epigenetic Regulation Of Gene Expression
Circadian Behavior
Promoter-specific Chromatin Binding
Regulation Of Stem Cell Population Maintenance
Negative Regulation Of Gene Expression
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of MiRNA Transcription
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