UBE2H and TRIM56

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2H	TRIM56
Gene Name		ubiquitin-conjugating enzyme E2H	tripartite motif containing 56
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Response To Type I Interferon Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Defense Response To Virus Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		57 interactors: BRAP BYSL CBLC CD99 DTX3 DTX3L DZIP3 EPS15 HDAC6 HIST2H2AA3 JADE1 LRSAM1 MARCH1 MARCH10 MARCH2 MARCH4 MARCH8 MKRN3 NEURL1 NHLRC1 POLL POLM RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 UBA1 UBASH3B UBOX5 UBR2	1 interactors: UBE2H
Entrez ID		7328	81844
HPRD ID		03052	10284
Ensembl ID		ENSG00000186591	ENSG00000169871
Uniprot IDs		A4D1L5 P62256	Q9BRZ2
PDB IDs		2Z5D
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Monoubiquitination Regulation Of Viral Release From Host Cell Metabolic Process Histone Ubiquitination Protein Catabolic Process Histone Monoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Regulation Of Viral Entry Into Host Cell Cellular Macromolecule Catabolic Process Cellular Process Negative Regulation Of Protein Metabolic Process Histone Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Viral Process Regulation Of ERBB Signaling Pathway Protein Trimerization Aggresome Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K6-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Chromatin Modification Negative Regulation Of Cellular Protein Metabolic Process Proteolysis Catabolic Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Negative Regulation Of Viral Entry Into Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination
Tagcloud ?		0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1	antiviral bodies compartments confer detects dimerization facilitated interacted interferon irak1 irf7 k63 nucleic pdcs plasmacytoid potently prerequisite recruit sense sting stranded tbk1 tlr7 tlr9 traf6 tripartite ubiquitination viperin
Tagcloud (Difference) ?		0e 1426a 219g 3072g abhd16a abhd5 acp2 alms1 apoa2 atp1a2 bft col14a1 ctsf dars decr1 ghrl intron3 mc4r mttp nfkbia nt5e pfp plat ppp2r5d rfc2 rragd sdhd serpinf1 tbc1d1	antiviral bodies compartments confer detects dimerization facilitated interacted interferon irak1 irf7 k63 nucleic pdcs plasmacytoid potently prerequisite recruit sense sting stranded tbk1 tlr7 tlr9 traf6 tripartite ubiquitination viperin
Tagcloud (Intersection) ?