UBE2H and HBP1

Number of citations of the paper that reports this interaction (PubMedID 29911972)
52

Data Source:
BioGRID (enzymatic study)

		UBE2H	HBP1
Description		ubiquitin conjugating enzyme E2 H	HMG-box transcription factor 1
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GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Wnt Signaling Pathway Regulation Of Cell Cycle
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	20 interacting genes: ANKRD2 CASP8 CD2AP CREBBP EP300 ESR1 EWSR1 HDAC1 KIFBP RB1 RB1CC1 RBL2 SAP30 SIN3A SMAD1 TCF4 TMEM37 UBE2H WDR26 ZNF212
Entrez ID		7328	26959
HPRD ID		03052	13634
Ensembl ID		ENSG00000186591	ENSG00000105856
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	B4DJ36 O60381
PDB IDs		2Z5D 8PJN	2E6O 3QVE
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K27 Acetyltransferase Activity Chromatin Cell Differentiation Sin3-type Complex Histone H3K18 Acetyltransferase Activity Transcription Corepressor Activity N-terminal Peptidyl-lysine Acetylation Regulation Of Transcription By RNA Polymerase II Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Stem Cell Population Maintenance Developmental Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II TFIIB-class Transcription Factor Binding Regulation Of Lipid Kinase Activity Rhythmic Process Regulation Of Gene Expression Transcription Coregulator Activity Regulation Of Macromolecule Biosynthetic Process Nucleus Cellular Developmental Process Protein-containing Complex Regulation Of RNA Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Complex Positive Regulation Of Stem Cell Population Maintenance Transcription Coactivator Binding Chromatin Organization Regulation Of Protein Localization To Nucleus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA Binding DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process P53 Binding Chromatin Remodeling Negative Regulation Of Biosynthetic Process N-terminal Protein Amino Acid Acetylation Regulation Of Stem Cell Population Maintenance
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