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UBE2H and HDAC6
Number of citations of the paper that reports this interaction (PubMedID
38113892
)
104
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
UBE2H
HDAC6
Description
ubiquitin conjugating enzyme E2 H
histone deacetylase 6
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Multivesicular Body
Centrosome
Cytosol
Cytoskeleton
Microtubule
Microtubule Associated Complex
Caveola
Cilium
Microtubule Cytoskeleton
Inclusion Body
Aggresome
Axon
Dendrite
Cell Leading Edge
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Neuron Projection
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Plasma Membrane Bounded Cell Projection
Axon Cytoplasm
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Conjugating Enzyme Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Corepressor Binding
Actin Binding
Histone Deacetylase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Zinc Ion Binding
Transferase Activity
Hydrolase Activity
Deacetylase Activity
Enzyme Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Protein Lysine Deacetylase Activity
Peroxidase Inhibitor Activity
ATPase Inhibitor Activity
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Alpha-tubulin Binding
Ubiquitin Binding
Metal Ion Binding
Acetylspermidine Deacetylase Activity
Tau Protein Binding
Beta-tubulin Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Dynein Complex Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Polyubiquitination
Response To Amphetamine
Chromatin Organization
Protein Deacetylation
Ubiquitin-dependent Protein Catabolic Process
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Intracellular Protein Transport
Autophagy
Response To Stress
Actin Filament Organization
Negative Regulation Of Microtubule Depolymerization
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Autophagy
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Mitochondrion Organization
Negative Regulation Of Neuron Projection Development
Macroautophagy
Regulation Of Macroautophagy
Axonal Transport Of Mitochondrion
Neuron Differentiation
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Protein Destabilization
Lysosome Localization
Positive Regulation Of Protein Oligomerization
Regulation Of Microtubule-based Process
Protein-containing Complex Disassembly
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Heat
Response To Immobilization Stress
Cellular Response To Topologically Incorrect Protein
Aggrephagy
Erythrocyte Enucleation
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Fat Cell Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Collateral Sprouting
Negative Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Dendrite Morphogenesis
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Cellular Component Organization
Response To Corticosterone
Mitochondrion Localization
Response To Misfolded Protein
Positive Regulation Of Synaptic Transmission, Glutamatergic
Cilium Assembly
Regulation Of Microtubule-based Movement
Regulation Of Androgen Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Cilium Disassembly
Type 2 Mitophagy
Regulation Of Biological Quality
Regulation Of Establishment Of Protein Localization
Cellular Response To Hydrogen Peroxide
Regulation Of Microtubule Cytoskeleton Organization
Aggresome Assembly
Polyubiquitinated Misfolded Protein Transport
Protein Targeting To Vacuole Involved In Autophagy
Cellular Response To Misfolded Protein
Cellular Response To Parathyroid Hormone Stimulus
Response To Dexamethasone
Tubulin Deacetylation
Macromolecule Deacylation
Polyamine Deacetylation
Spermidine Deacetylation
Membraneless Organelle Assembly
Positive Regulation Of Cellular Response To Oxidative Stress
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Cholangiocyte Proliferation
Positive Regulation Of Type 2 Mitophagy
Negative Regulation Of Aggrephagy
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HSF1 activation
Notch-HLH transcription pathway
Cargo trafficking to the periciliary membrane
Transcriptional regulation by RUNX2
RUNX2 regulates osteoblast differentiation
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
Valproic acid
Decitabine
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Romidepsin
Panobinostat
Phenylbutyric acid
Entinostat
Abexinostat
Givinostat
Pyroxamide
Bufexamac
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
31451708
)
Lymphocyte count (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Response to antidepressants and depression (
27622933
)
White blood cell count (
32888494
)
Interacting Genes
71 interacting genes:
BRAP
CBLC
CD99
CDK2
DTX3
DTX3L
DZIP3
EPS15
GID4
GOLGA2
H2AC18
H2AC20
HBP1
HDAC6
JADE1
LNX2
LRSAM1
MAEA
MARCHF1
MARCHF10
MARCHF2
MARCHF4
MARCHF8
MDM2
MKRN3
NEURL1
NEURL2
NHLRC1
POLL
POLM
PRKN
PSME3
RAG1
RBX1
RELA
RNF10
RNF103
RNF113B
RNF114
RNF128
RNF133
RNF139
RNF144A
RNF146
RNF166
RNF185
RNF186
RNF2
RNF34
RNF38
RNF4
RNF6
STAM2
STUB1
TLE5
TRAIP
TRIM13
TRIM17
TRIM2
TRIM23
TRIM28
TRIM36
TRIM37
TRIM5
TRIM56
TRIM69
TRIM72
UBASH3B
UBOX5
UBR2
UBR3
83 interacting genes:
ADRB2
APOBEC3G
ARHGDIA
ATF3
BBS10
BCL3
BCOR
BRMS1
CDKN1A
CEP70
CRBN
CSNK2A2
CYLD
DSCR9
DYNLL2
EP300
ERBB2
ERBB3
ERBB4
FBP1
FBXO11
FNTA
FNTB
GRK2
H2AX
H4C16
HDAC11
HES1
HTATIP2
HTATSF1
ISG15
JDP2
KPNA1
LCOR
LINC00624
LPXN
MAPK1
MAPK3
MAPT
MLH1
MOB1A
MSH2
NACAD
NASP
NEDD8
NR0B2
NR3C1
PLAA
POLA2
POLDIP2
POLR1B
PPP1CC
PRDX4
PRKCZ
PRKN
PROM1
PTOV1
PXN
RELB
RNF168
RNF31
RUNX2
SEPTIN7
SIRT2
SYK
TEKT4
TPPP
TRIM50
TUBA1B
TUBA4A
TUBB
TUBB2B
UBB
UBC
UBE2D1
UBE2D3
UBE2E1
UBE2H
USP10
VCP
VKORC1
ZBTB16
ZNF205
Entrez ID
7328
10013
HPRD ID
03052
02228
Ensembl ID
ENSG00000186591
ENSG00000094631
Uniprot IDs
A0A3B3IU20
A4D1L5
P62256
B4DZH6
Q9BRX7
Q9UBN7
PDB IDs
2Z5D
8PJN
3C5K
3GV4
3PHD
5B8D
5EDU
5KH3
5KH7
5KH9
5WBN
5WPB
6CE6
6CE8
6CEA
6CEC
6CED
6CEE
6CEF
7ZYU
8G43
8G44
8G45
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Transferase Activity
Protein Modification Process
Zinc Ion Binding
Protein Metabolic Process
Protein Polyubiquitination
Metal Ion Binding
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Autoubiquitination
Macromolecule Metabolic Process
Macromolecule Catabolic Process
Proteolysis
Protein Catabolic Process
Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Ligase Complex
Protein Monoubiquitination
Ubiquitin Protein Ligase Binding
Protein K63-linked Ubiquitination
Autophagy
Positive Regulation Of Catabolic Process
Cytoplasm
Endoplasmic Reticulum Mannose Trimming
Protein K48-linked Ubiquitination
Regulation Of Protein Catabolic Process
Protein Alpha-1,2-demannosylation
Suppression Of Viral Release By Host
Immune System Process
Protein Deglycosylation
Aggresome Assembly
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
ERAD Pathway
Endoplasmic Reticulum Quality Control Compartment
Cellular Response To Stress
Protein K6-linked Ubiquitination
Ubiquitin Binding
Inclusion Body Assembly
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Autophagy
Aggresome
Defense Response To Symbiont
Defense Response To Other Organism
Nucleus
Protein Modification Process
Cytosol
Protein Ubiquitination
Post-translational Protein Modification
Modification-dependent Protein Catabolic Process
Negative Regulation Of Metabolic Process
Protein-containing Complex
Protein Modification By Small Protein Conjugation
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Response To Stress
Microtubule Cytoskeleton
ERBB2-ERBB3 Signaling Pathway
ERBB3 Signaling Pathway
Regulation Of Protein Modification Process
ERBB2 Signaling Pathway
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Deacetylation
Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Histone Deacetylase Binding
Ubiquitin Protein Ligase Binding
Macromolecule Metabolic Process
Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Developmental Process
Nucleoplasm
Protein Tag Activity
Regulation Of Signal Transduction
Negative Regulation Of RNA Biosynthetic Process
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Regulation Of Gene Expression
Regulation Of Protein-containing Complex Assembly
Glial Cell Differentiation
Positive Regulation Of Developmental Process
DNA Damage Response
Cell Differentiation
Cellular Response To Stress
Developmental Process
Regulation Of DNA-templated Transcription
Regulation Of Signaling
Regulation Of Cell Communication
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Tagcloud (Intersection)
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